"The atmosphere in the lab was really phenomenal," post-doctoral researcher alumnus Stanley Maloy recalls of his time in what is now the University of Utah’s School of Biological Sciences.

"People talked to each other and argued with each other and made suggestions to each other. I thought it was the way science should be done."

Maloy's connection to the U began when he arrived in1981 to work with John Roth, whom colleagues had described to him as "the best bacterial geneticist in the world." Though initially considering other opportunities, it was his visit to Roth's lab that changed Maloy's trajectory.

During his three years at the U (1981-1984), Maloy worked on a then-controversial area of genetic regulation — how genes can auto-regulate themselves. His research challenged the scientific dogma of the time and laid the foundation for his subsequent 30 years of NIH-funded research. In 2024 Maloy was designated a Distinguished Alumnus, recognizing his significant contributions to microbiology, national security, entrepreneurship, and scientific ethics over a career spanning more than three decades.

A Unique Scientific Community

Unlike many postdoctoral experiences where researchers interact primarily within their own labs, the U fostered a broader scientific community. "The group here was phenomenally interactive," Maloy explains. Monthly evening seminars brought together researchers from across disciplines to critically analyze each other's work. "It was the love of thinking about science, considering other explanations, and pondering about what might be wrong."

This culture of rigorous scrutiny fostered what Maloy values most in science: "For science to really serve its purpose, to really reflect reality, it demands that not only that you publish things, but you think through them, that you argue through them, you talk about different applications, different explanations."

From Basic Research to Biotechnology Applications

After leaving Utah, Maloy joined the University of Illinois at Urbana-Champaign in 1984, where he spent 18 years rising through the ranks to full professor. Throughout his career, he has bridged basic science and practical applications through entrepreneurship.

Maloy has been involved in founding several biotechnology companies, each building upon his fundamental research in bacterial genetics. One company focused on "getting bacteria to evolve new functions quickly," with applications in detergents and other chemical processes. Another venture developed neuropeptides, which later spun off into a company focused on creating novel antimicrobials "of types that didn't exist before."

Perhaps the most promising entrepreneurial effort involves cancer therapeutics. Initially conceived as a vaccine platform, the company pivoted when pre-COVID funding for vaccines proved difficult to secure due to legal risks. Instead, they developed targeted delivery systems for treating specific types of cancer resistant to conventional therapies, such as hormone-resistant prostate cancer.

"That company has products in clinical trials right now for types of cancer that there's no other therapy for," Maloy notes proudly. Having passed initial safety trials, the treatments are now being evaluated for efficacy — potentially offering hope where few options currently exist.

Leadership in Scientific Integrity

Beyond his research and entrepreneurial ventures, Maloy has emerged as a leader in scientific ethics. He recently took over authorship of a widely used textbook on scientific integrity and responsible conduct of research, which is required reading for students working on NIH grants.

Working with colleagues from Michigan and Duke University, Maloy is currently completing a comprehensive revision addressing emerging challenges in scientific ethics, including paper mills, inappropriate citations, and the impacts of artificial intelligence on research integrity.

"Most people in society can't distinguish science from pseudoscience," Maloy explains, underscoring why maintaining scientific integrity is crucial. "If we let these false things become really prevalent, then people will say, 'Oh, look, you know, there's 500 articles on this thing. So it clearly must be right.'"

His latest project involves using virtual and augmented reality to create emotional experiences that help researchers internalize ethical principles. “There is compelling evidence that if somebody really emotionally experiences it, they will more rapidly change their behavior," he explains, demonstrating his innovative approach to tackling even non-scientific challenges.

Despite disappointments when projects Maloy has invested significant time and effort into face setbacks or changes in direction due to shifting political landscapes, his work in the Republic of Georgia has proven meaningful. In Georgia he and his team have established an SDSU branch to help transform their post-Soviet higher education system to support its future without permanent dependence.

A Distinguished Legacy

In his emeritus role at San Diego State University, Maloy continues to conduct research through industry collaborations while generously yielding his university laboratory space to make room for new assistant professors.

His recognition as a Distinguished Alumnus by the U celebrates not only his scientific and entrepreneurial achievements but also his commitment to the rigorous, collaborative approach to science that he first experienced in Salt Lake City—an approach that has informed his entire career and now shapes his work to strengthen scientific integrity for future generations.