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Regenerating damaged heart tissue. Sound Fishy? (It is)

REGENERATING DAMAGED HEART TISSUE. SOUND FISHY? (IT IS)


April 18, 2024

Utah biologists discover that tiny tropical fish's "superpower" lies in an immune response to heart injuries.

Clayton Carey, a postdoctoral researcher in the Gagnon lab and lead author on the new study. Credit here and above: Brian Maffly

A heart attack will leave a permanent scar on a human heart, yet other animals, including some fish and amphibians, can clear cardiac scar tissue and regrow damaged muscle as adults.

Scientists have sought to figure out how special power works in hopes of advancing medical treatments for human cardiac patients, but the great physiological differences between fish and mammals make such inquiries difficult.

So University of Utah biologists, led by assistant professor Jamie Gagnon, tackled the problem by comparing two fish species: zebrafish, which can regenerate its heart, and medaka, which cannot.

A tale of two fish

The team identified a few possible explanations, mostly associated with the immune system, for how zebrafish fix cardiac tissue, according to newly published research.

“We thought by comparing these two fish that have similar heart morphology and live in similar habitats, we could have a better chance of actually finding what the main differences are,” said Clayton Carey, a postdoctoral researcher in the Gagnon lab and lead author on the new study.

Gagnon’s team wasn’t able to solve the mystery—yet—but their study shed new light on the molecular and cellular mechanisms at play in zebrafish’s heart regeneration.

“It told us these two hearts that look very similar are actually very different,” Gagnon said.

Both members of the teleost family of ray-finned fish, zebrafish (Danio rerio) and medaka (Oryzias latipes) descended from a common ancestor that lived millions of years ago. Both are about 1.5 inches long, inhabit freshwater and are equipped with two-chamber hearts. Medaka are native to Japan and zebrafish are native to the Ganges River basin.

According to the study, the existence of non-regenerating fish presents an opportunity to contrast the differing responses to injury to identify the cellular features unique to regenerating species. Gagnon suspects heart regeneration is an ancestral trait common to all teleosts.

Understanding the evolutionary path that led to the loss of this ability in some teleost species could offer parallel insights into why mammals cannot regenerate as adults.

With their distinctive horizontal stripes, zebrafish have long been popular as pets in the United States. In the 1970s zebrafish were embraced by biologists as a model organism for studying embryonic development of vertebrates.

Scientists like zebrafish because they can be propagated by the thousands quickly in labs, are easy to study and proved to be extremely hardy.

Read the full story by Brian Maffly in @The U

Gentrification drives patterns of alpha and beta diversity in cities

Gentrification drives patterns of alpha and beta diversity in cities


April 18, 2024
Photo: Mountain lion in the Wasatch Mountains. Credit: Austin Green.

Over the past two decades, a return of investment and development to once-neglected neighborhoods has meant a significant increase in spending on restoring parks, planting trees and converting power and sewer easements into publicly accessible greenspaces.

That trend — sometimes called “green gentrification” — tended to raise property values, helping to price out many neighborhoods’ original inhabitants. That led to an obvious question: What had those changes done to local animal populations, and what might that say about the changing dynamics of how nature functions in American cities?

This requires a staggeringly complicated analysis, and a new study published earlier this week in Proceedings of the National Academy of Sciences (PNAS), a vast and diverse array of data includes nearly 200,000 days of camera trap surveillance, taken over three years across almost 1,000 sites in 23 U.S. cities each with a unique mammal population, pattern of urban development and interaction between the two.

Austin Green, PhD

Some of that data have been accumulated by conservation ecologist Austin Green, a post-doctoral researcher and Human/Wildlife Coexistence stream leader in the acclaimed Science Research Initiative (SRI) at the College of Science. Leveraging the citizen science movement in the intermountain region, Green and his SRI team played a critical role in assembling a cohesive, detailed data-driven narrative of how gentrification  — when lower-income people are forced out from American neighborhoods — the animal populations in the areas they’re leaving behind shift toward local species less typically associated with city environments. In turn, this phenomenon adds to the larger conversation in the U.S. about the reach and complexity of racial inequity.

Green's research is part of a monumental effort to collect and interpret data that have global implications about how humans and wildlife co-exist, especially in this case, as it relates to the continuing gentrification of cities, where more than 58 percent of the world population lives. Informed by Green's work in the SRI program combined with that of many others', scientific breakthroughs, as illustrated in the PNAS study, can directly influence conservation and adaptive management strategies.

Students in this particular stream at the U learn about wildlife ecology and conservation, as well as how to conduct ecological fieldwork, design complex studies of animal behavior and human-wildlife coexistence, curate and format large scale-datasets, and conduct advanced statistical analysis.

 

You can read the full article by SAUL ELBEIN in The Hill about this fascinating research and its findings published in PNAS here.

 

 

Metallurgical Engineering and IperionX Unveil New Research Facility

Metallurgical Engineering and IperionX Unveil New Research Facility

The new lab follows announcement of 10-year, $10 million agreement with titanium industry leader IperionX

Following the 10-year, $10 million research agreement announced earlier this year between the University of Utah’s Department of Materials Science and Engineering and Charlotte-based IperionX, the two partners, along with college and university leadership, celebrated the opening of a new state-of-the-art additive manufacturing research center on campus in the William Browning Building. The lab, which houses cutting-edge 3D titanium printing machines, will serve as a hub for the collaboration between Metallurgical Engineering Professor Zak Fang's powder metallurgy research team and IperionX as they work to advance metallurgical technologies for producing primary metals focused on titanium.

The opening of the lab, named the Titanium Additive Manufacturing Research Center, creates new opportunities for U students to gain hands-on experience with cutting-edge materials science and engineering technologies. The partnership aims to inspire the next generation of metallurgical innovators, equipping them with the skills and experience needed to pioneer breakthroughs in sustainable metal production and processing.

IperionX CEO Taso Arima.
Banner photo: Ribbon cutting, led by Provost Mitzi Montoya and IperionX CEO Taso Arima.

"This new lab represents the tangible fruits of our partnership with IperionX and underscores our shared commitment to developing transformative solutions for the energy and transportation sectors," said Fang, the lead researcher on the project. "By combining our academic expertise in materials science and engineering with IperionX's industry know-how and resources, we are poised to make significant strides in areas like additive manufacturing of titanium alloys and recycling of critical minerals."

IperionX’s role as a leader in sustainable titanium production is a key component of this collaborative research effort. The North Carolina-basecompany has patented technologies aimed at recycling the valuable metal at a lower cost and with reduced environmental impact compared to traditional methods. 

“IperionX is excited to continue its extensive collaboration with the University of Utah and Dr. Zak Fang,” said IperionX CEO Taso Arima. “It all started here at the University of Utah, with Dr. Fang’s innovation and his vision for manufacturing and re-shoring low-cost, high performance titanium metal in America. The Titanium Additive Manufacturing Research Center will allow us to continue to rapidly innovate, and we believe this center and continued work with Dr. Fang and his research team will assist to attract students to materials science and engineering — because this is what drives innovation for the critical technologies needed for the U.S. and society as a whole.”

"This academic-industry partnership of the Fang Lab and IperionX exemplifies the College of Science’s innovative bench-to-application research to meet the needs of our energy future," said Peter Trapa, Dean of the College of Science. "By supporting cutting-edge research that addresses real-world challenges, we are cultivating the next generation of scientific leaders and driving economic growth in Utah."

Joint efforts with industry partners have been part of the U's remarkable research growth over the past decade. In fiscal year 2023, university research funding reached a landmark $768 million, nearly doubling its support in the last ten years. As the U continues to work towards a goal of $1 billion in research funding, its leadership views industry collaboration as a vehicle to accelerate discovery and translate research into real-world applications.

“Collaborations like this one are virtuous cycles,” said Richard Brown, H. E. Thomas Presidential Endowed Dean of the John and Marcia Price College of Engineering. “Cutting-edge research and industry supporting one another is the backbone of a growing innovation economy.”

by Bianca Lyon

 

Goldwater Scholars 2024

Goldwater Scholars 2024

Two College of Science students awarded the prestigious Goldwater Scholarship for 2024-25

The Barry Goldwater Scholarship is a prestigious award given to undergraduate sophomores and juniors who intend to pursue research careers. Goldwater Scholars often go on to hold distinguished research and leadership positions across many disciplines. For the 2024-2025 academic year, 438 scholarships were awarded to college students across the country. At the University of Utah, two undergraduate students have earned the honor of becoming Goldwater Scholars: Muskan Walia and Nathan Patchen.

Nathen Patchen
Biochemistry

“Biochemistry was a great way for me to combine my love of biology and chemistry and understand not only how things work, but why,” says Nathan Patchen about what motivated him to pursue research in that field. Patchen was awarded the Goldwater Scholarship for his work in Yang Liu’s lab, an assistant professor of biochemistry at the Spencer Fox Eccles School of Medicine

Patchen describes his research as broadly being focused on DNA damage repair. He says “[w]e have access to revolutionary gene editing tools that, when used in conjunction with advanced imaging techniques, allow us to explore how cancer cells undergo DNA damage repair as never seen before. Personally, I am doing this by implementing a modified CRISPR-Cas9 that allows us to capture time-resolved images after damage and then produce data about the kinetics of repair.” 

After graduating from the U, Patchen hopes to pursue an MD/PhD to practice medicine while continuing his research on gene editing and aging. Outside of his time in the lab, he enjoys being active through swimming, biking, and running as he trains for an IRONMAN 70.3 in St. George, Utah in May. 

 

Muskan Walia
Mathematics
Philosophy

“Mathematics is at the cusp of interdisciplinary research” says Muskan Walia. During the College of Science ACCESS Scholars research program, she reflected on her academic interests and goals. She explains, "I wasn’t interested in studying any discipline in a vacuum or in isolation. Rather, I wanted to work on mathematics research that centered justice and informed public policy.”

The majority of Walia’s undergraduate research sprouted from her time in ACCESS where with the help of Fred Adler in the mathematics department at the College of Science, she began to adapt an epidemiological SIR model to predict the number of cells infected with SARS-CoV-2. Since then, she has created other models to further answer her questions about disease. These include a “... model of disease progression within an infected individual, a model of an antigen test, and a model of symptoms to evaluate how testing can be used to limit the spread of infection.”

“Ultimately, I want to lead a team that utilizes mathematical principles to tackle the most pressing social justice related questions of our time.” Walia is one of 57 awardees honored this year who intend to pursue research in mathematics or computer science. Besides innovating mathematical models, Walia enjoys spending time outside bird watching with her mom and gardening with her grandmother.

 

 

By Lauren Wigod
Science Writer Intern

 

 

 

Utah Refugee Teens Build Cosmic Ray Detectors

Utah Refugee Teens Build Cosmic Ray Detectors


April 11, 2024

This collaborative cosmic ray project connects refugee youth to science

 

On April 9, 2024, a community of refugee students and their families, scientists, educators and policymakers will celebrate an event three years in the making—the installation of five cosmic ray detectors atop the Department of Workforce Services Refugee Services Office (also known as the Utah Refugee Center) in downtown Salt Lake City. The detectors, which measure echoes of cosmic particles bombarding Earth’s atmosphere, were built by nearly 60 participants in a program called “Investigating the Development of STEM-Positive Identities of Refugee Teens in a Physics Out of School Time Experience (InSPIRE)”, which brings science research—in this case particle physics—to teenagers and contributes to a worldwide effort to measure cosmic ray activity on Earth.

“Refugee youth often encounter many challenges related to STEM, including restricted exposure to STEM education, language barriers, cultural adjustments and a history of interrupted schooling, resulting in a low rate of high school completion and college matriculation among refugee students,” said Tino Nyawelo, principal investigator of InSPIRE and professor of physics and astronomy at the U. “The project conducts research to better understand these challenges and how to best broaden access to and engagement in STEM for refugee youth and other historically disenfranchised populations.”


Tino Nyawelo kicks off the cosmic ray detector installation celebration at the Utah Refugee Services Center on April 9, 2024. (Photo: Todd Anderson)

InSPIRE brings together the University of Utah, Utah State University, Utah Department of Workforce Services Refugee Services Office, as well as the Dutch National Institute for Subatomic Physics (Nikhef) in Amsterdam, to involve teens in real science. Data from the students’ cosmic rays detectors helps us understand the origins of the universe. The celebration is on Tuesday, April 9, at 1:30 p.m. at the Refugee Services Office at 150 N. 1950 W., Salt Lake City, UT 84116. A short ceremony will include speakers from the U, USU and the Refugee Services Office, and two student-participants will be available with research posters to talk about their cosmic ray detection projects.

Funded by a $1.1 million grant from the U.S. National Science Foundation in 2020, InSPIRE explores how refugee teenagers identify with STEM subjects while they participate in a cosmic ray detector-building and research project. Fifty-seven refugee teens spent one-to two-days a week for nearly three years building the detectors while learning the principles of particle physics and computer programming. The students designed their own research projects, posing questions such as whether the moon impacts cosmic rays. While some participants focused on the detectors, others focused on crafting short films on their fellow students’ research journeys. These students are working on a documentary, in partnership with the ArtsBridge America program at the U’s College of Fine Arts.

Neriman (left) and Lina Al Samaray with a poster of their research project, Effect of the Moon on Cosmic Ray Detectors. The high highschoolers used data from existing HiSPARC detectors to investigate whether the moon’s position from the horizon impacted the rate of cosmic rays hitting Earth’s surface.(Photo: Lisa Potter)

InSPIRE is embedded within Refugees Exploring the Foundations of Undergraduate Education In Science (REFUGES), an after school program that Nyawelo founded to support refugee youth in Utah’s school system, who are placed in grade levels corresponding to their ages despite going long periods without formal education. The U’s Center for Science and Mathematics Education (CSME) has housed the REFUGES program since 2012, where it has expanded to include non-refugee students who are underrepresented in STEM fields. Since then, REFUGES has worked closely with the state of Utah’s Department of Workforce Services Refugee Services Office, which serves as a critical link to the refugee community by coordinating comprehensive services to refugees resettled in our state.

“For the past 12 years, the Refugee Services Office has collaborated with the REFUGES program to identify refugee students and their families who need academic assistance and support. Participation in REFUGES keeps these students engaged in their community while also promoting their access to educational opportunities,” said Mario Kligago, director of the Utah RSO. “It’s amazing—what started as a small project funded by a Refugee Services Office grant has grown into a multi-million dollar endeavor backed by national organizations.”

The detector technology is adapted from HiSPARC (High School Project on Astrophysics Research with Cosmics), a collaboration between science institutions that started in the Netherlands, aimed at improving high schoolers’ interest in particle physics. There are now more than 140 student-built detectors on buildings in the Netherlands, Namibia, and the United Kingdom that upload their data 24/7 to publicly available databases. Nikhef in Amsterdam coordinated the project from 2003-2023 and created the initial worldwide network of cosmic ray detection data. Starting in 2024, data on extensive cosmic air showers and the digital HiSPARC infrastructure will be hosted and maintained by the U’s Center for High Performance Computing (CHPC), led by professor Nyawelo.

Read the full article in @TheU.

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2024 Class of SIAM Fellows: Aaron L. Fogelson

2024 Class of SIAM Fellows: Aaron L. Fogelson


April 4, 2024

The Society for Industrial and Applied Mathematics (SIAM) has honored Aaron L. Fogelson's distinguished work with its fellows program.

 

This year's 26 esteemed fellows were nominated in recognition of their outstanding research and service to the community. Through their various contributions, SIAM Fellows form a crucial group of individuals helping to advance the fields of applied mathematics, computational science, and data science.

A professor of mathematics at the U, Fogelson, who lists his research interests as mathematical physiology, modeling of blood clotting, gels and viscoelastic fluids and numerical solution of partial differential equations (PDEs), is being recognized by SIAM for his pioneering work on mathematical modeling and numerical methods for platelet aggregation and blood clotting.

"Clotting is an extremely complex process with physical, chemical, and cell biological components which is essential to maintaining the integrity of our circulatory system," he writes on his faculty profile. "When it malfunctions the consequences can be dire, including heart attack and stroke. Clotting is subject to intense research by laboratory and medical scientists but its complexity makes it very difficult to think through how it works or to make predictions about how well medical interventions to treat clotting problems will work. That is where mathematics and the work I do comes in."

On his lab's website, Fogelson writes, "Because transmural pressure differences vary greatly in the circulatory system and because blood flowing at different speeds through vessels of widely varying diameter leads to great variation in shear stress, the challenges of forming a blood clot to stop the outflow of blood differ substantially in different vascular beds. The system that has evolved to cope with these disparate challenges involves the aggregation of cells (platelets) and the formation of fibrous protein gel (fibrin). In addition, there is a complex, powerful, and tightly regulated enzyme network (the coagulation system) involving reactions on the surfaces of activated platelets, that leads to production of an enzyme, thrombin, that is key both in activating platelets so they can cohere to one another and in forming the protein fibrin from which the fibrin mesh is constructed."

40 Years of Modeling Clotting

The Fogelson research group has been developing models of many of the disparate aspects of blood clotting for close to 40 years. "We have built and analyzed models based on PDEs, ODEs [ordinary differential equations], or SDEs [stochastic differential equations] and, as needed, we have developed novel numerical methods with which to study the PDE-based models," writes Fogelson.

Projects of current interest in this research space includes, first, developing ODE-based compartment models of platelet deposition and coagulation under flow that treat developing thrombi as porous materials and which can track resulting flow, the growth of aggregates, and the biochemistry of platelet signaling and coagulation from the initiation of clot formation through vessel occlusion. The goal is a high-throughput simulation tool that will allow extensive investigation of model behavior as model parameters and other inputs are varied to reflect different physiological situations and disease states.

A second project of interest is integrating the Fogelson lab's models of fibrin polymerization with models of platelet deposition and coagulation under flow during arterial thrombosis, to produce a more comprehensive model of the clot formation process.

Fogelson has been a faculty member at the U since 1986 after earning his PhD at the Courant Institute of Mathematical Sciences of New York University and working as a post doctoral researcher at first the University of California, Berkeley and then the Courant Institute. In addition to his faculty position in the U's Department of Mathematics, he is adjunct professor of biomedical engineering, and was Associate Dean for Research of the College of Science in the period 2014-17. His research has been supported by the National Science Foundation and/or the National Institutes of Health continuously since 1982.
Read about all 26 SIAM fellows announced here.

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Biology Student Stories: Bailey Landis

Biology Student Stories: Bailey Landis


April 3, 2024

by Maisy Webb

From playing the clarinet and majoring in music to finding inspiration in deciphering the As, Ts, Gs, and Cs relevant to fruit fly evolution and genetics, Bailey Landis has many interests but has dedicated his educational pursuits to biology.

The “major” shift happened when Bailey took Genetics from Nitin Phadnis. That was the moment he realized he loved biology and wanted to give research a try.

Bailey asked Phadnis if he knew of any lab openings, and the very next day he entered the research world…in the Phadnis lab! “Even though research was new to me, I was given the opportunity to jump into cutting-edge science. I immediately began investigating the genetic basis of a hybrid incompatibility between two subspecies of Drosophila.” Bailey artfully explained that “When two populations of a species are isolated from each other, they rapidly evolve [and this can] lead to speciation.” Deciphering the molecular and genetic basis of this process is the focus of the Phadnis lab.

Bailey finds the lab environment “unequivocally amazing” and  “is inspired by the motivation and drive of his peers in the lab.” He says, “Whenever you are doing something, people want you to do well ... and are not hoping for your downfall. So I have gotten courage knowing when I am presenting or doing something scary that people are hoping to see me succeed.”

Bailey has gained an appreciation for the collaborative nature of science, receiving mentorship and mastering new techniques with support from two other biology professors, Kent Golic and Clayton Dale. As it goes in research, things often don’t work and you always have to be on the lookout for something unexpected, Bailey shared. “I became frustrated that my hard work had yielded no results and began doubting whether the X-ray machine was working correctly. I examined the neuroblasts of mutagenized males, looking for fragmented chromosomes to ensure that the genetic material was being irradiated. ... My irradiation approach was simple and reliable [yet] lacked efficiency, relying on randomly mutating a single gene out of over 13,000. I felt like I was waiting for an accident and wanted my approach to be more precise. I returned to the drawing board, searching for a more efficient way to identify this gene. I pivoted to a targeted deletion system using CRISPR/Cas-9.”

Bailey’s enthusiasm and dedication has led to an evolution in his knowledge, which will definitely give him a head start when he begins his PhD in biology, at the U, in the fall of 2024.

Bailey is from Chico, California. When he’s not in the lab, you can find Bailey indulging his many other interests from drawing and painting, fly fishing, working on his jiu jitsu, snowboarding, and cooking lots of different dishes!

 

This article originally appeared at the School of Biological Sciences

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Placing geology at the foundation of essential discoveries

Placing geology at foundation of essential discoveries


March 29, 2024 | Carleton College

by Daniel Myer 

Above: Professor Bereket Haileab leads a geology field trip in 2023.

Bereket Haileab, MS'88, PHD'95, chair and professor of geology at Carleton College, is a researcher and teacher animated by his passion for geology.

Bereket Haileab

Haileab has been a cornerstone of geology at Carleton College, a small, private liberal arts college in the historic river town of Northfield, Minnesota, since he joined the faculty in 1993. Through his research over the years, he has also helped rejuvenate the study of the guiding principles behind his discipline, and connected that work with the larger Northfield and Carleton communities. His experiences, ranging from studying Rice County’s hydrology to helping chart the founding story of the entire human species, have revealed the role geology plays in multiple major disciplines. Today, he teaches these lessons to new generations of students, and shows that the College’s geology department is a true testament to the quality of a Carleton education.

At first, Haileab’s work had a utilitarian angle. After his undergraduate education at the University of Addis Ababa in Ethiopia, he had the opportunity to study for his PhD with well-known geochemists at the University of Utah. “There,” Haileab said, “I got the skills to do chemical analysis, interpret the results, and write about it.”

These experiences solidified his background in geochemistry, petrology, and mineralogy, which Haileab used to become an exploration geologist with the Geological Survey of Ethiopia. In his role, Haileab surveyed regions of western Ethiopia to find new gold deposits. Although he found the chance to apply his skills in chemical analysis fulfilling, he was interested in getting more involved with the interdisciplinary field of paleoanthropology — the study of human evolution through fossils, cultural artifacts, and more — which his graduate school experiences had introduced him to.

“When I came to Utah, I went to the field every summer and met many [experts in paleoanthropology] there and in meetings,” Haileab said. “My research was used in every place.”

Those who study the origin of the human species, like paleoanthropologists, depend on extensive geological research. With a lot of their modern work based on the fossils of early people or closely related species, scholars and scientists also need those fossils’ detailed geological contexts, including the current state and geologic history of their dig sites. After all, Haileab said, “you don’t find fossils floating by themselves.”

In 1985, Haileab joined a University of Utah research group working in Kenya, where just one year prior, the “Turkana Boy,” a Homo ergaster, was discovered. Haileab’s group needed to map the surrounding Turkana Basin in order to refine the dating process that allowed geologists and paleoanthropologists to prove that the Turkana Boy was 1.6 million years old. Haileab’s research, however, expanded far beyond one basin.

“We found that the volcanic ash from Turkana, to the sediments of the Red Sea cores, to the sediments in the Gulf of Aden, all the way south to Lake Albert in Uganda, to Ethiopia… was all formed originally [in the Turkana Basin], which makes it the most important point,” Haileab said. “For most of the fossiliferous [fossil rich] sediments, we could correlate all of the sedimentary basins and all of the findings temporally.”

Read the entire article at Carleton News.

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Hunting an underground epidemic

Hunting an underground epidemic


April 3, 2024

Above: The research team outside Toquerville, UT. Left to right: Kimberly Hanson; Kevin Perry; Alyssa McCoy; Katrina Derieg; and Schuyler Liphardt.

In 2001, 10 archaeologists working at a dig site in northeastern Utah suddenly fell ill with a respiratory illness that sent eight of them to the hospital, coughing and feverish.

The symptoms resembled pneumonia, but their diagnosis was unexpected. It was Valley fever, a fungal infection that spreads to people through spores in the soil and dust—and it wasn’t supposed to be there. Valley fever is more common in hotter, drier states; previous predictions of where the fungus could survive in the soil barely extended into the southwest corner of Utah. The archaeologists’ dig site, in Dinosaur National Monument, was hundreds of miles outside the disease’s expected borders.

The truth is, nobody really knows which areas of the state harbor Valley fever. But the archaeologists’ plight shows that its fungal culprit could be far more widespread than anyone predicted. And as the climate changes, the fungus will likely spread further, explained Katharine Walter, assistant professor of epidemiology at the Spencer Fox Eccles School of Medicine at the University of Utah.

A person bends over samples in a shade tent.

PHOTO CREDIT: KATRINA DERIEG

Eric Rickart in the field outside Santa Clara, UT.

 DOWNLOAD FULL-RES IMAGE

“There have been incredibly intense recent changes in temperature as well as precipitation and drought here in the American West. These all impact the range of where the fungus can exist,” said Walter.

Walter is on a mission to map where in Utah the Valley fever fungus can survive and predict how it will move across the landscape as the climate changes. Walter and her collaborators—Katrina Derieg, vertebrate collections manager at the Natural History Museum of Utah; Eric Rickart, adjunct associate professor of biology at the U and curator of vertebrates at NHMU; and Kevin Perry, professor of atmospheric sciences in the U’s College of Mines and Earth Sciences—recently received a $375,000 Climate and Health Interdisciplinary Award through the Burroughs Wellcome Fund to power their fungus hunt and raise awareness of what to do for the people most at risk of infection.

Read the full story by University of Utah Health's Sophia Friesen in @TheU

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The Beauty of Mathematics

THe beauty of Mathematics


April 2, 2024


by Fred Adler

After listening to an egregiously (and quite uncharacteristically) dull math colloquium some years ago, I had a revelation that there are three good reasons to do mathematics:  it is important (solves an open problem), it is useful (cures cancer) and it is beautiful.

 

These good reasons are not mutually exclusive, and my own ideal, rarely achieved, is to combine all three. In case you are curious, the dull talk exemplified one of the bad reasons (it is hard), that I'll say no more about.

So what is this vaunted mathematical beauty? Is mathematical beauty the same as beauty in the arts and nature, or does it just happen to go by the same name?

Faced with a problem of this magnitude, poet and Distinguished Professor Katharine Coles and I decided to do what we do best. Talk about it. This year's Symposium on Science and Literature takes on the idea of beauty, bringing together poet Claudia Rankine, physicist Brian Greene, and neuroscientist/artist Bevil Conway for three days of discussion. As part of the preparation, we are jointly teaching a course this semester on the theme of Beauty to a small class of remarkable students, half from math, half from English. The English students are facing the trauma of making sense of math and physics and attempting to see the beauty therein. The Math students are facing the terror of making sense of complex poetry and attempting to see its beauty. And we are all taking on the collective challenge of reading philosophy to peek behind the curtain to ask what beauty is.

At the atomic scale, when one sheet of atoms arranged in a lattice is slightly offset from another sheet, moiré patterns can create some exciting and important physics with interesting and unusual electronic properties. (Image courtesy of Ken Golden)

Before revealing the answer, I'll share some of the mathematical ideas we have discussed, largely following the charming “The Joy of x by Stephen Strogatz, inspired by his popular series for the New York Times online called "The Elements of Math.” Given the mixed group, the mathematics, in the spirit of Strogatz's book, is fundamental and not technical.

We began with an age-old question: What does the golden ratio have to do with rabbits? The golden ratio appears in geometry, describing the shape of a rectangle that is supposedly the most appealing to the eye, and appearing in the elegant logarithmic spiral. But this number also shows up as the limit of the ratio of the consecutive values of the Fibonacci sequence (1,1,2,3,5,8,13,21...). Each number is the sum of the previous two numbers, and the sequence can be generated by counting the population of immortal and fecund rabbits who produce babies every month and take just two months to mature. The beauty, we decided, lies in the unexpected connection of geometry and arithmetic.

The most elegant and venerable link between geometry and numbers is the Pythagorean theorem, that the sum of the squares of the sides of right triangle is equal to the square of the hypotenuse. Where do those squares come from anyway? I know three broad classes of proof. The first is rather pretty, involving drawing squares on the sides and hypotenuse and cleverly chopping them to get them to match. The second, which I came up with when I couldn't figure out how to do the first, is rather ugly, involving drawing lines, taking ratios, and doing a bunch of nasty algebra. The best proof, which I had not seen before, was attributed to the teenage Einstein in one of the books we read for the class ``A Beautiful Question" by Nobel-prize winning physicist Frank Wilczek. It is based on what we mean by area. If you take any shape and make it twice as big by stretching equally in all directions, the area gets bigger by a factor of 4. That's where the squares come from if you made the shape 3 times as big, the area would be 3^2=9 times bigger. Rather than building on tricky drawing or algebra, this proof requires adding just one line to the picture, and then thinking. In mathematics, beauty lies in deep simplicity. And, as in music and the arts, that kind of simplicity has to be earned.

Fred Adler writes equations inside his office at the University of Utah in Salt Lake City on Sept. 5, 2023. (Photo by Marco Lozzi | The Daily Utah Chronicle)

I became interested in mathematics because of the magic of numbers. And large numbers have an allure all their own. The Fibonacci series, like rabbit populations, grows rather fast. But what if you want to write down really huge numbers? We can use the way that mathematical ideas build on themselves, recalling the progression of arithmetic in elementary school. Addition is repeated counting (6+7=13 means counting to six and then counting to seven). Multiplication is repeated addition (6*7=42 means adding up seven 6's). Exponentiation is repeated multiplication (6^7=279936 means 6*6*6*6*6*6*6, multiplying together seven 6's). The numbers are starting to get pretty big. But to really turbocharge, let's try repeated exponentiation. Donald Knuth invented "arrow notation" to handle this question. ­6­­↑↑7 is 6 raised to the 6th power seven times, or 6^6^6^6^6^6^6. There's really no way to say how big this number is. Even 6­­↑↑3 has 36,305 digits written in decimal notation. But no matter how absurdly large these numbers become, they are still nothing compared with infinity. The beautiful has the sense of the inexhaustible, the beauty of a poem, the face of one you love.

We have touched on many other mathematical questions. Is the quadratic formula ugly, or does it have "inner beauty"? Is there a beautiful poetry behind the existential angst of probabilities? Will I ever get over my prejudice against fractals?

Along the way, we've learned a few things. Good things happen when geometry and algebra get together. Beauty has an element of surprise, evoked by connections between apparently different things. Beauty arises when complexity meets simplicity and when simplicity meets complexity. Einstein was a beautiful and deep thinker. Keats was a great poet who evoked deep thoughts with beautiful words.

There is a toast attributed variously to G.H. Hardy and other famous mathematicians: “Here’s to pure mathematics. May it never be useful for anything!” The Enlightenment philosopher Immanuel Kant argues that beauty indeed must lie outside anything useful, attractive or even morally good. But mathematics has the remarkable power to surprise us with beauty when it seeks to be useful, and with usefulness when it seeks beauty.

Fred Adler is Professor of Mathematics and Director of the School of Biological Sciences at the University of Utah.

The 2024 Science and Literature Symposium takes place April 10-12. This year's topic arises from reexaminations of beauty that are occurring broadly not only in the arts and across such disciplines as ethnic and disability studies, but also in biology, where dominant theories about the possible evolutionary purposes of beauty are being questioned. 

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