The School of Biological Sciences claims all of our alumni, but sometimes there’s a kind of harmonic convergence that elevates an entire family of U biologists into the spotlight.

Such is the case with the Idaho Daines Family of orthopedic surgeons—Joseph “Pete,”,BS’68; Michael, BS’99; and Brad, BS’05—a virtual dynasty in orthopedic surgery. Brian, who as an undergraduate attended BYU (the U’s traditional rival to the south) also practices orthopedics but in Arizona. The oldest son Gordon was the outlier. He found his passion in history and is now a university archivist with a doctorate in education.

The University of Utah Daines Dynasty goes back three generations, beginning in 1920 when the grandfather of Pete’s wife Susan--also mother to his sons--attended undergraduate school at the U and then went on to medical school in New York City, ultimately returning to the west to start a general medical practice in Preston.

Michael Daines, MD

Born in 1945, Pete was at first a math major at the U but changed to biology/pre-med before attending Columbia Medical School followed by an orthopedic residency at George Washington University. His father, who died a year after Pete’s return to Idaho in 1979, also practiced orthopedics in Boise.

Years later Pete’s son Michael would also graduate from the U and head east to medical school at Columbia College of Physicians and Surgeons, followed by a residency in orthopedics at the University of Iowa. Later he was awarded a fellowship to Oxford University to study shoulder surgery for a year. He now specializes in shoulder surgery in addition to general orthopedic surgery at West Idaho Orthopedics near Boise, where he and his siblings grew up.

Not to be outdone by his older brothers, Brad entered medical school at the University of Washington following his graduation from the School of Biological Sciences. Subsequently, he completed a residency at the University of Vermont in orthopedic surgery followed by fellowship training in total joint replacement at the Hospital for Special Surgery/Cornell University. Brad focuses on hip and knee replacement which can include robotics.

For the first few years in practice, his father Pete was his assistant in the operating room. “I ended up not really quitting totally, from practice until 2018,” Pete says. In addition to assisting Brad, he provided medical evaluations for insurance companies, conducted independent exams and wrote up patient histories and reports for attorneys. "To have my dad with me has been an awesome experience” Brad said in a 2016 KBOI 2News story “because he is sort of a calming presence."

"How does it feel seeing three of your four boys following in your footsteps?" the reporter asked Pete in the same story. "Well,” said the patriarch, “it's sort of an ego trip, but I think it's great. I just wanted my sons to do something that they enjoyed." Says Brad, "Like my brothers, I always thought I was going to be a doctor. I didn't ever feel any pressure, but I noticed that my dad liked his job."

Clearly orthopedics is in the Daines Family blood, and clearly the University of Utah’s Biology Department--now the School of Biological Sciences--played a role in the family’s success.

Both Michael and Brad remember the invaluable experience they had in the Biology Undergraduate Research Program (BioURP) with Rosemary Gray, now an emerita faculty. Michael was a research assistant with Sandy Parkinson while Brad found a research mentor in Dave Carrier. “I learned a lot from him about the scientific method,” says Brad. “In addition, because his work did involve animal subjects, I learned much about the balance of the ethical treatment of animals and the need for scientific advancement. We worked with canine subjects, and the length to which he went to ensure good care of these animals was impressive.”

Additionally, Brad really found his groove in the honors program and his upper level biology classes were also an incredible experience, particularly, he remembers, comparative vertebral morphology. Membership in the University Chorus and Sigma Chi fraternity gave him a musical and social outlet.

Both brothers recall the “incredible athletic programs” at the U which gave them a reprieve from the lab and the classroom. Along with sports, there was a love of the mountains and skiing. The combination of the Daines family legacy, recreational opportunities and the academic reputation of the U would converge for a memorable experience for both.

Michael’s research experience in the Parkinson lab was a segue for Columbia Medical, his father’s alma mater. While in New York City, Michael had the singular experience of living through the attacks on the World Trade Center on September 11, 2001. Later, during his Oxford fellowship in the UK, he also worked on several research projects related to the shoulder.

An avid hunter, fisherman and triathlete, Michael enjoys spending time with his three kids, along with his hunting dog “Hawkeye.”

For all of the Daines, there have, of course, been challenges due to the current pandemic, including for Brian in Arizona who, his father remarks, finds himself overworked, doing “everything” related to joint medicine in a small clinic.

“I traveled a lot with my wife,” says Pete, remembering pre-COVID-19 times when he floated European rivers through places like Budapest and Vienna, sometimes through spectacular tunnels 30 miles long. A music enthusiast, he also sang bass in a choir and for five years sat on the board of the Boise Philharmonic. Along with Michael Brad also loves to fish and with his father enjoys music, opera in particular.

While the pandemic has slowed these activities, it has consorted to bring the family, which now includes thirteen grandchildren, closer together. Clearly the spread of the coronavirus has impacted the Daines and their respective medical practices just as it did Pete’s early relatives during the 1918 flu pandemic. “It was a bad pandemic as well,” Pete says, referencing family letters left behind, but “nothing like this one. [Back then] they lost family, this, that and the other thing. It took two years to get past it. That’s what it does. It comes and turns your life upside down.” Even so, he says, the earlier pandemic didn’t keep people out of work as much as the current one.

Says Michael, “I have had to navigate the need to care for patients and also keep my office staff safe. As a small business owner, we have had to find creative solutions to keep people working and keep the doors open.” Brad, too, has had to make the adjustments to the way he works.  “Life is always uncertain,” he says, referring to the past year. His advice? “Remain flexible and do the best you can every day. Embrace the fact that life will take you down unexpected paths. Upon reflection, many of the best things in my life happened when my plan deviated.”

Michael agrees: “Take your opportunities when they come up and have no fear!”

Will the Daines tradition of orthopedic surgery carry on into the next generation? “I think there’s going to be some of my grandkids going into medicine,” says Pete. “It probably isn’t going to be the conglomeration [of a medical life] like I got. I don’t know how that happened,” he quips, referring to three-fourths of his progeny who are surgeons.

“They just wanted to go and they did. Back then I could take my kids into the operating room with proper supervision and they could watch things. You can’t do that now. It’s not allowed. I had that opportunity to have some stuff in the operating room and I think that cemented for them going into medicine…. I didn’t mean for them to all become doctors, but that’s what happened. I’m very proud of them.”

As for Brad, his children are still too young (7 and 5) to have shown any interest in a career in medicine-- yet."

When David Hillyard, BS’73, was recognized in November with a Healthcare Hero Award, he was quick to share the love. “This honor should really go to the fantastic team of individuals I’ve been working with who have made high-capacity, quality COVID testing possible,” Hillyard said. “It’s very flattering, but every day I just think about the critical contributions front-line laboratory workers make for this effort every day.”

The sentiment is typical of the collaborative and generous nature of the Professor of Pathology at the University of Utah School of Medicine and founding Director of Molecular Infectious Disease Testing at ARUP, the largest academic laboratory in the country.

“This year, Utah’s healthcare leaders went above and beyond, pivoting their time, creativity, ingenuity, and magnanimity to face off against a global pandemic,” read the Utah Business citation. “This is only the beginning of our nation’s battle against COVID-19 … and we are so grateful to these warriors for leading the charge.”

Hillyard’s interest in the U started with a love of Ute basketball in the era of its legendary coach Jack Gardner, known as “the Fox,” who shepherded five All Americans, including Billy “The Hill” McGill.

“In high school, I visited the U for hosted debate and drama competitions and got a glimpse of its campus. I never thought I could afford to go out-of-state for college and saved all of my earnings … to be able to pay for at least a first year at the U.”  Scores of lawn mowings later and he had tuition which at that time was $175 per quarter. “I also had the academic blessing,” he says,“ of my Uncle Charlie, a renowned nuclear physicist, who received his PhD at the U and gave the science departments a high rating.”

Hillyard’s acceptance to the U was transformative for the Ogden native whose “first rate education” in biology and chemistry was elevated by the extraordinary opportunity to participate in basic research beginning his sophomore year. Professor K. Gordon Lark would arrive during Hillyard’s sojourn in the Department of Biology, now the School of Biological Sciences, and the legendary chair, who passed away in April, turbo-charged the department with newly recruited faculty of outstanding molecular biologists and distinguished visiting professors.

The expanding breadth and rigor of the department was an accelerant to Hillyard, allowing for him graduate level exposure to biology as an undergraduate but most importantly, he says, personal mentoring in bioresearch in “a thrillingly fun environment. Without question, these short years were the foundation for a happy career and any professional successes to come.”

As an undergraduate in Dr. Baldomero “Toto” Olivera’s lab, he worked on differences in pathways and magnitude of turnover of the metabolic cofactor NAD in e. colio and Hela cells.  “My fondest memories of my time at the U are informal dinner parties with lab mates and visiting scientists at the home of [Toto]” he recalls, adding that the “[l]ate night jaunts with Toto to the Roadway Inn for apple pie ala mode and experiment planning rank way up there too.” Many would agree with him that Olivera’s mentoring of undergraduates at the U is legendary.

Later, with the advent of polymerase chain reaction (PCR), a kind of molecular photocopying now commonly used in biology labs, Hillyard collaborated with Olivera on the identification and cloning of conopeptide genes from venomous marine snails, groundbreaking work that has since been widely celebrated as a potential replacement for opioids and their vaulting addictive properties. “As a clinical pathologist,” says Hillyard, “my work has focused on molecular infectious disease test development and the clinical application of these tests.”

Following graduation from the U, Hillyard pursued medical training at Columbia University’s College of Physicians and Surgeons in New York City along with fellowship training in pathology. He then returned to the U for fellowship training in microbial genetics and medical microbiology followed by a position as assistant investigator with the Howard Hughes Medical Institute at the U’s School of Medicine. He also joined the faculty of the Department of Pathology.

Hillyard figured prominently in establishing a test to meet the nationwide demand for diagnosing COVID-19. Beginning in January he and researchers at ARUP validated one of the first high-throughput diagnostic COVID-19 tests in the nation. With Emergency Use Authorization from the U.S. Food and Drug Administration in late February 2020, Hillyard and his team worked around the clock to ensure they had a test ready to launch in March with a turnaround time of less than two weeks.

More recently Hillyard and his team have worked on developing co-tests for Covid-19/Flu AB/ and respiratory syncytial virus. “The scale and urgency of the project has certainly been challenging and a bit life changing,” he confesses, “but is dwarfed by the positive experiences of working with teams of dedicated laboratorians stepping up to the plate with their hard work, problem-solving, and commitment to do good.”

“There are so many surprises with COVID-19 that you’re never fully prepared, no matter how ready you think you are,” said Hillyard in the Utah Business profile in November, as he described preparing for flu season with cases continuing to rise. “The flu season hasn’t been very bad in the southern hemisphere this year, perhaps because of physical distancing and other measures taken to mitigate COVID-19 spread, but the flu will come.”

The good doctor’s COVID-19 research has been in collaboration with Boston-based Ginkgo Bioworks whose co-founder Reshma Shetty is another celebrated alum of the Olivera lab. Together with other government and non-profit health organizations they’ve studied the genetics of the virus in Utah and analyzed how its molecular makeup is evolving. The consortium has also conducted a major study comparing testing accuracy across different labs and instrument platforms.

No doubt the pandemic has been a singular time for all of us, but being on the frontlines of infectious disease testing has put a megaphone on all of it for Hillyard. Beyond family, he takes refuge in bicycling, especially hill climb racing. “I also love hiking, photography and as a wellness advocate for my department, [I] enjoy keeping up on the latest in food science. Unfortunately," he admits, "I’m a terrible cook."

Terrible in the kitchen or not, in his typical generous fashion Hillyard is quick to offer thoughtful advice to the next generation of scientists and health professionals. “[T]rain broadly, recognizing the importance of multiple skill sets for a successful career,” he says. “I would also suggest seeking out the best mentors at the best institutions in an environment where you can build personal relationships and also have fun.”

Dr. David Hillyard is a model U Biology alumni, transforming his immersion in undergraduate research with star, engaged faculty to a most elevated and award-winning legacy underscored by public service.

Uncle Charlie, it turns out, was right.