Ribosome adventures

Venki Ramakrishnan, 'My adventures in the ribosome'


Venkataraman “Venki” Ramakrishnan’s story is the stuff of fiction. He went from an eager undergraduate student in India to a self-described “failed physicist” to a major player in the race to uncover one of biology’s biggest mysteries—the structure of the ribosome, the most important molecule that nobody’s heard of that earned him a Nobel Prize in chemistry in 2009.

The opportunity to research the ribosome drew Ramakrishnan to the University of Utah in the late ‘90s. The ancient molecule brings him back as a Nobel laureate to discuss his “Adventures in the Ribosome” at the College of Science’s Frontiers of Science Lecture Series on Sept. 26, at the Natural History Museum of Utah. The evening should be enthralling—his popular memoir Gene Machine reads like a thriller that navigates inspired collaborations, friendly rivalries, and cutthroat competition behind scientific discoveries and international accolades.

“Why did my career work out? I didn’t go to any famous schools for my undergrad or graduate school, and I was sort of an outsider most of my life. I think there’s some sort of general lessons there,” Ramakrishnan said. “One of them is if you find things don’t work out, you have to be open to change.”

Ramakrishnan has never been afraid of change. He earned a PhD in theoretical physics at the University of Ohio, but immediately realized that developing theories and mathematical calculations wasn’t for him. The field of biology grabbed his attention.

“Every issue of Scientific American when I was a grad student was full of big breakthroughs in biology. That was a time when the first sequences of DNA were being reported, Ramakrishnan said. “Biology was going through this huge revolution, and it hasn’t stopped.”


Read the full story by David Pace and Lisa Potter in @TheU.
Read more about the Ribosome exhibit, in conjunction with Ramakrishnan lecture, at the Natural History Museum of Utah.