bio-news
Galápagos Letters
January 17, 2022
Adventure Awaits
Getting ready for a field expedition is always an adventure. After packing, COVID testing, homework, buying supplies, planning travel, and coordinating a study, we are very ready to be on our way. Read More >

January 24, 2022
El Garrapatero
Our first day in the field we went to “El Garrapatero.” Meaning “Tick Eater,” both the site and its namesake, which happens to be a beach, are named after a common bird called an Ani. Read More >

January 31, 2022
Philornis Downsi
Philornis downsi is well known because its larvae are harmful to bird nestlings. The larvae suck blood, hence the “vampire” part of their name. Read More >

February 7, 2022
Lions, Iguanas, and Birds
People and wildlife share the space, which means you have to be careful not to step on an iguana or sit too close to a sea lion! Read More >

February 14, 2022
Field Observations
Readers should note that biologists, grad students, and intrigued 13-year-olds may stop frequently to observe things. Read More >

February 21, 2022
Galápagos Portraits
If it’s true that a picture paints a thousand words, you will have several thousand to read today! Read More >

February 28, 2022
Plumber’s Camera
We’re beginning to look inside the nests with a camera, taking notes on the contents of each. Read More >

March 7 2022
It’s a Small World
Every day, walking around town, to the beach, the station, or on our patio outside, our group constantly points out ants, carpenter bees, geckos, millipedes, katydids and grasshoppers. Read More >

March 14, 2022
Galápagos Penguins
We woke up early to get ready, and catch a bus to the dock on the other side of the island. The drive went through the highlands, where it was beginning to rain. Read More >

March 14, 2022
Old Town Quito
The city, full of people, is so different from Puerto Ayora. The streets are packed with shops and each big hill is covered in bright colorful buildings. Read More >

Originally published @ biology.utah.edu
April Christofferson
April Christofferson

April Christofferson
“I love the process of writing,” says April Christofferson, BS’73, “but I write because I’m trying to make a difference.”
The difference this Illinois native is talking about includes many of the most complex and conflicted issues of her adopted home in the American West, including wildlife and public lands management, tribal rights, and development. Most recently her passion as a writer has turned to the issue of more than 6,000 missing and endangered indigenous women in the country, many of them in the West.

Trapped ©2012
This year, the reissue of the first two books of her Judge Annie Peacock Series, Alpha Female and Trapped, by Burns & Lea Books–along with its shopping of them by publisher/agent Story Merchant for a television miniseries based on the characters’ adventures in Yellowstone National Park and beyond—speak to the enduring interest of her literary creations, characterized by deep-dive storytelling that started more than a quarter-century ago.
Growing up in Chicago, Christofferson came to love the West during summers visiting Yellowstone and her grandfather’s ranch in Wyoming, where both parents had been raised, and later her paternal grandparents’ homes in Salt Lake City and Richmond, Utah. But the road she traveled to become a successful writer is a long and winding story in itself.

Edgewater ©1998
In many ways, it starts with Christofferson’s maternal grandfather, Floyd “Doc” Carroll, a rodeo champion and Wyoming state veterinarian who was inducted into the National Cowboy & Western Heritage Museum’s Hall of Great Westerners in 1998. He was a stunt double for the famous movie cowboy Tom Mix. “My grandpa was such an influence,” says Christofferson. “I knew from when I was a little girl that I was going to live out West and be a vet.”
After receiving her undergraduate degree in biology from the U, Christofferson began a veterinary medicine program at the University of Illinois in Champaign. But after her first year, she realized she truly wanted to be back West.
“Throughout college, I worked at an animal hospital, but I was always upset—they would try not to tell me if someone was bringing in an animal to be euthanized, because I’d do anything I could to persuade them not to” if treatment were at all possible, she recounts in the alumni story by Marcia C. Dibble. “I realized I wasn’t really emotionally cut out to be a vet.”

The Protocol ©2000
Christofferson and her husband, Steve Leach—also a Utah graduate, BS’76, communication—quickly relocated to Coeur d’Alene, where April focused her love of animals on rescuing those in need. She began a series of odd jobs waitressing, loading UPS trucks, and working as a pharmaceutical rep, while determining what else she could channel her passion into next.
A friend began nudging her toward romance writing, telling her anecdotes about others who had made the transition from completely unrelated careers.
“I thought, I don’t have a creative bone in my body, but I had just turned 40, so I sat down and wrote a scene about it—and I just got hooked that day.”

Clinical Trial ©2001
It wasn’t a straight line between getting “hooked” on writing and publishing her first novel. Inspired by her oldest sister, Christofferson attended law school at nearby Gonzaga University in Spokane, where she graduated with a JD in 1983, followed by a stint as counsel at the Seattle-based entertainment company Miramar. But she continued to write, and for her first book, After the Dance, set in the entertainment industry with which she was then intimately familiar, the underlying issue was that of a family dealing with the death of a son from AIDS.
After the novel’s release by a small publisher in 1994, Christofferson swiftly got an agent and quit Miramar to write full time. After the release of her second book, Edgewater, she promptly signed a book deal with national publisher Forge Books.
Her next three novels, The Protocol, Clinical Trial, and Patent to Kill, were all medical thrillers. She centered the plots of the second and third of these thrillers on the abuse of indigenous peoples, a theme first introduced into her work in Edgewater. Her next book, Buffalo Medicine, focused on the slaughter of bison that wander outside the boundaries of Yellowstone.

Patent to Kill ©2005
Following the publication of Buffalo Medicine, she started getting gratifying feedback that helped her see that her work was making that difference she had always hoped it would.
Alpha Female, the first in the series now being shopped for television, revolves around poaching (in this case, of wolves) and addresses the threat to national parks from drilling.
In addition to using her writing as a vehicle for educating readers, Christofferson currently devotes time to Footloose Montana, a grassroots nonprofit she helped found, which is dedicated to protecting all wildlife, including predator species. She presently serves on the advisory board.

Alpha Female ©2009
Now a resident of Bozeman, Montana, where her son and one of her two granddaughters live, Christofferson has a full life. It includes regular visits to the Blackfeet Reservation, where her daughter and other granddaughter live, writing daily in a small but cozy outbuilding, hanging out with her kids/grand daughters and husband, and, of course, entertaining a herd of furry friends, currently featuring five cats and four dogs, including an “all heart” black lab. Always, there are animals nearby, a tribute to her original impulse to be a veterinarian, now turned to animal rescue with her husband, the executive director of an animal shelter in the town of Livingston, north of Yellowstone in the Absaroka Mountains.

Grizzly Justice ©2019
Christofferson’s most recent book Grizzly Justice is about a recently fired ranger who disappears into the backcountry, hell-bent on saving a wounded grizzly bear whose fate is all but certain: euthanasia. Her current project Wolf Killer is more than timely; it feels ripped from the headlines after Montana Governor Greg Gianforte was reported to have trapped and killed a collared Yellowstone wolf who had wandered 10 miles out of the protected space of the park. (Gianforte was given a written warning for failing to take the required trapping course).
Even though she had started drafting the manuscript before the incident, the wolf, who was named “Max,” became a cause celebre. The issue of wolf hunting in Montana and the American West is classic Christofferson fodder for the kinds of stories she excels at rendering.
Generously, she attributes the beginning of those stories in part to her undergraduate years in Salt Lake City. “I’m a big fan of the University of Utah,” says Christofferson, recalling the extra semester she spent after graduation working on the University Health campus, and her senior project in biology, when she had been studying the molting of snakes.
“I was obsessed with snakes,” she says. “I had 20 of them [Coluber constrictor foxii, commonly known as “blue racers”] in an aquarium in the greenhouse. I would go up there, weigh them, record my observations.” One day when she arrived, someone had left the aquarium open, “and there I was lying on the floor of the greenhouse, trying to catch snakes, with my husband helping me,” she says with a laugh.
We will have to wait to see if that story ends up in one of her books.
By David Pace, first published @ biology.utah.edu
This story is an excerpt and update of Marcia C. Dibble’s profile of Ms. Christofferson that appeared in the U’s Continuum, now Utah Magazine, in winter 2007-08.
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Charles Sorenson
Charles Sorenson
“My best trait is the ability to hang out with people who are far more capable than I am,” says Charles Sorenson, MD, FACS, in a 2020 interview. “I am not intimidated by working with people who are smarter than I am.”
The former president and CEO of Intermountain Healthcare, the Salt Lake City-based nonprofit regional healthcare system, and by some measurements the largest employer in Utah, must have been “hanging” with some pretty capable and smart people over the years . . . and vice versa. Now Emeritus CEO, the U Biology alumnus, HBA’74, has a long history at Intermountain as a urologic surgeon and physician leader. Today he serves as Founding Director of Intermountain Healthcare Leadership Institute.

Charles Sorenson
The Salt Lake City native attended the University of Utah as a pre-med honors student with designs to go back east for professional school. Once he’d been accepted to Cornell Medical, he quickly learned that his undergraduate education had prepared him as well for graduate work “as Ivy League educations had done for my classmates. I’m particularly grateful for the extraordinary learning experiences I had through the Honors College,” he says.
He remembers his time as a student at what is now the School of Biological Sciences as a place with an “atmosphere of open dialogue, people who challenged my ideas and encouraged me to challenge theirs. Professors who genuinely cared about their students, some of whom became lasting mentors and models of professionalism and personal integrity.”
There were several U professors who were “remarkably engaging and committed.” But the one who had the most long-term influence on Sorenson was Homer R. Warner, MD, PhD former chair of the Dept of Biophysics and Bioengineering. In the honors class Warner taught there were just a handful of students, including Sorenson. “Homer was a brilliant, world-recognized innovator in the emerging field of computers in medicine. I ended up working in his lab for three years while going to school. He was an inspiring model of a dedicated physician scientist and also a leader who cared more about others than himself.” To Sorenson the doctor scientist remained a dear colleague, friend, and mentor until Warner passed away in 2012.
“I was a pretty good student,” says Sorenson in a Managed Healthcare interview, “and I wanted to go to medical school because it was the hardest thing I could think of doing, I always felt like doing hard things was good for me, and I always felt like this is what I always wanted to do.” The budding physician also had the example of his own father, a Salt Lake internist and of his mother, a nurse.
Sorenson’s penchant for leaning into “hard things” paid off. After Cornell, he returned to the U for his residency in general surgery and urology. Before his stint as CEO, Sorenson spent 11 years at Intermountain as executive vice president and chief operating officer.
During that time, he played a critical role in making clinical process improvements and developing Intermountain into an integrated delivery system. Beginning in the 90s, healthcare services nationwide were fragmenting and patients were no longer as much at the center of the equation as Sorenson believed they should be. To help remedy that, he teamed up to establish Intermountain Medical Group, an integrated practice of 1,500 physicians and advanced practice clinicians employed by the organization. Sorenson served as founding chair of the group’s board from 1994 to 1998.
Even after being coaxed into a full-time leadership role at Intermountain, Sorenson spent one day each week in surgical practice. That was fine with the board. They didn’t want him to go get an MBA; they wanted someone who understood clinical processes and frontline employees to further the organization’s mission.

Charles Sorenson
That approach was eventually recognized shortly after Sorenson stepped down as CEO when he was awarded the 2017 Distinguished Service Award from the University of Utah’s School of Medicine. The accolade is given to healthcare leaders who’ve made outstanding contributions to the school, the community, and the practice of medicine. At the time Ron Larkin, MD, a retired OB/GYN and former Intermountain trustee, said of Sorenson’s honor, “He has as much integrity as any person I’ve ever met. He’s completely always wanting to do the right thing. He’s got such great intellect and such great judgment. He does do the right thing.”
If it sounds like under the leadership of Sorenson Intermountain has been re-inventing American healthcare as a mission-driven, patient-centered and employee-happy enterprise, that’s because it was, so much so that in 2009 President Barack Obama held the system up, more than once, as a model of quality, low-cost, integrated patient care.
About that acknowledgement from the White House Sorenson said, “While it’s easy for all of us, who know Intermountain so well from the inside, to focus mostly on ways we can still improve, it’s important to step back from time to time and appreciate the progress we’ve made. The president’s comments are a tremendous validation of the extraordinary work of our people in every one of Intermountain’s facilities and services.”
It seems that Charles Sorenson is always deflecting what are arguably his accomplishments back to his loyal front-line workers—in fact to everyone who together makes “hard things” happen well and economically at Intermountain.
It’s called leadership, the execution of it and the training of others in it, something that Sorenson is deeply embedded in now as Director of the Healthcare Leadership Institute. Even the advent of the coronavirus pandemic could not stop him. “We transitioned our program at the … Institute from an intensive on-site two weeks for healthcare leaders to an all-virtual, three-month program. While we look forward to being able to return to our beautiful Institute with in-person programs, virtual sessions have been well received and highly rated by participants—so they’ll always be a component of our program.”
These days Sorenson has had more time to spend with his four adult children and his grandchildren. With his wife Sharee, he has spent time volunteering, including working with refugee families from Central Africa. He has served on the Board of Providence Health, a very large not-for-profit health system based in Seattle, since 2018. He also recently joined MEDI, the largest executive coaching firm in the nation dedicated exclusively to the healthcare industry as an executive coach.
With more time on his hands, he enjoys music, hiking and biking and catching up on his reading. Some recent favorites have included The Second Mountain by David Brooks, Churchill by Andrew Roberts, The Culture Code by Daniel Coyle, Sea Stories by William McRaven, After by Dr. Bruce Greyson, and Facing the Mountain by Daniel James Brown.
In addition to modeling his notion of hanging out with people whom he believes are smarter than he, Charles Sorenson’s advice to students is trenchant as they navigate a world that can be taxing and at times even despairing:
- Have the courage to embrace new ideas—even if they initially seem to challenge your own ways of thinking. But be careful not to be dragged along by what seems fashionable today but is not based on sound logic or in the best long-term interests of society.
- Never neglect your personal values—always striving to improve and raise those values to higher levels.
- Be very careful about those with whom you spend your time— professionally and personally. We become, for better or for worse, like the people with whom we spend our days.
- Learn to be a “forever learner,” and help others to do the same.
- Be generous and be grateful. You’ll be the greatest beneficiary of the help and thanks you extend to others.
- It is advice from a leader and a coach of health executives that stems from a lifetime of achievement . . .of doing “hard things.”
By David Pace, first published @ biology.utah.edu Photos by Jeffrey D Allred, Desert News
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Sarmishta Kannan
Sarmishta Kannan

In the entrance of the Eccles Health Sciences Education building.
For Sarmishta Diraviam Kannan, HBS’17, the journey to her “dream school” – the University’s School of Medicine – spanned about 25 years and some 8,780 miles.
Sarmishta was born in Tamil Nadu, India, which is located on the southern tip of the Indian sub-continent. In addition to the long history of the Tamil people, Tamil Nadu is famous for its temples, festivals, and celebration of the arts.
When Sarmishta was just nine years old, her family immigrated to the United States. They settled in Boston where her father worked for GE Healthcare. In 2008, the family moved to Salt Lake City, near the corporate headquarters of GE Healthcare, while her father continued his career with the company.
Sarmishta, who was then 12 years old and in junior high school, was still mastering English as a second language and adjusting to social norms and public education systems in America.
It was a difficult time for Sarmishta, but her “dream” was beginning to form.
Sarmishta graduated from Hillcrest High School, in Midvale, in 2013 with the International Baccalaureate (IB) diploma.
“The IB diploma is a rigorous program, and I was the only one to take the higher-level courses in all three sciences of physics, chemistry and biology,” says Sarmishta. “It was through the IB program that I found my passion in the sciences, especially biological sciences, and completing the IB program prepared me well for college.”
Sarmishta decided to attend the U as an undergraduate because of the abundance of research opportunities and the Honors degree option in Biology which gave her the chance to perform long-term research that culminated with an Undergraduate Thesis. Plus, it put her in close proximity to the School of Medicine.
The “dream” was clear now and within reach.
“The Honors thesis requires involvement in research that finishes with writing a paper on a particular research project. That experience was valuable to me as I got the opportunity to be involved in a research project from start to finish,” says Sarmishta.
She worked with Dr. Kevin Jones at the Huntsman Cancer Institute to help discover the roles that lysosomes and autophagy play in alveolar soft parts sarcoma, clear cell sarcoma, and synovial sarcoma.
“In the Jones lab, it was fascinating for me to see how researchers used experimental data to understand cancer biology. So, I decided to pursue sarcoma research for my thesis,” says Sarmishta.
“I investigated the hypothesis that Alveolar Soft Parts Sarcoma (ASPS) and Clear Cell Sarcoma (CCS) morphology is attributed to lysosomes and that these cancers up-regulate autophagy genes using autophagy as a survival mechanism,” says Sarmishta.
“I learned to design investigations and troubleshoot various lab protocols to gather data and test the hypothesis. Critically analyzing the data supported the hypothesis that ASPS and CCS contain abundant autophagic lysosomes. However, it raised further questions indicating more research was necessary to better understand autophagy’s role in ASPS and CCS.”
“Writing my thesis taught me to build an evidence-based argument based on my data, critically analyze the work of others, synthesize new ideas for further research, and effectively communicate complex topics,” says Sarmishta.
Her thesis abstract was published in the 2016 University of Utah Undergraduate Research Journal. She also presented her thesis to Utah legislators at the Research on Capitol Hill event in 2017 and at Undergraduate Research Symposiums in 2016 and 2017.
After graduating with an Honors degree in Biology, she continued to work in the Jones lab as a full-time Lab Technician before starting medical school. She worked on various projects including writing a review manuscript on sarcomagenesis, titled Genetic Drivers and Cells of Origin in Sarcomagenesis, which was published in early 2021 in the Journal of Pathology.
She also worked on a project that focused on modeling synovial sarcoma metastasis in mouse models. Sarmishta was listed as a co-author on that paper and was published in the Journal of Experimental Medicine.
In the meantime, Sarmishta applied to the School of Medicine in 2019 and in 2020 and was accepted in 2020.
Finally, her “dream” was realized.
Today, Sarmishta is about halfway through her second year of the MD program at the University’s School of Medicine.
“It has been a very fulfilling experience so far! I am grateful to have the opportunity to follow my passion, learn about the human body, help and support people going through healthcare challenges. I am excited to start my clinical years where I get to rotate through various specialties in the hospital and apply all the knowledge I have been learning to patient care,” says Sarmishta.
In addition to school, she enjoys reading, painting, watching movies and singing.
In fact, Sarmishta is a classically-trained Carnatic singer. Carnatic music is a traditional system of music from India that provides a nearly limitless array of melodic patterns. It emphasizes vocal performance.
“I started singing when I was five and my parents enrolled me in Carnatic music classes in India. I continued my training after moving to the United States,” says Sarmishta.
“I perform publicly at the local Hindu Temple and at Indian festivals. One of my most cherished experiences was performing a Hindu song at the 6th Parliament of World Religions event, that was held in Salt Lake City.”
Sarmishta is scheduled to complete the MD program in 2024.
“A new dream is already forming,” she says.
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Of Mice and Monarchs
Of Mice and Monarchs

Sara Weinstein, Postdoctoral Researcher
Monarch butterflies possess a potent chemical armor. As caterpillars, they eat plants filled with toxic cardenolides that build up in their bodies and make them unpalatable to most—but not all—predators. In central Mexico, where the largest winter monarch aggregations occur, scientists observed that rodents attack monarchs that fall to the ground. In particular, the black-eared mouse (Peromyscus melanotis) specializes in these bitter-tasting insects, eating as many as 40 per night.
In a new study, University of Utah biologists found that mice at California monarch overwintering sites can also consume monarch butterflies. Working at one of the largest monarch aggregations outside of Mexico, Pismo State Beach Monarch Butterfly Grove, the researchers discovered that the western harvest mouse (Reithrodontomys megalotis) also ate the grounded monarchs. However, with the precipitous decline in western monarch populations, this butterfly buffet may be in jeopardy.

A harvest mouse munching on a monarch.
The authors do not think that rodents are contributing to the western monarch decline, nor that the monarchs are the only thing that mice can eat. Rather, documenting this new feeding behavior is a reminder of how little we know about the interactions that may be lost as insect populations decline.
“We are in an insect apocalypse right now. There are estimates that 40% of studied invertebrate species are threatened and that over 70% of flying insect biomass is already gone. This is devastating on its own and is also going to have enormous impacts on the other organisms that feed on insects,” said Sara Weinstein, the postdoctoral researcher who led the study.
“Western monarchs and other western butterflies need conservation attention and part of that awareness-raising is illuminating the many ways these animals are interconnected to other insects, birds, mammals, as well as our human communities. This study helps us appreciate more deeply how fewer butterflies means less food for other native animals” said Emma Pelton, senior conservation biologist at the Xerces Society.

Weinstein with a lab-reared monarch.
The study published in the journal Ecology on Dec. 12, 2021.
To study mouse-monarch interactions, the researchers first trapped rodents in the grove in February 2020. The rodents were released, but their feces were kept to screen for monarch DNA—which they found in one sample. This first survey occurred in late winter as monarchs were leaving the aggregation and few remained for mice to munch. Weinstein and colleagues intended to return the following fall during peak monarch season. However, after years of decline, the western monarch population crashed.
“At a site where 100,000 butterflies used to roost, in 2020 there where were fewer than 200 monarchs. So, we had to change tactics,” Weinstein said. “We tested whether rodents would feed on the butterflies using captive-reared monarchs.”
Weinstein set up lab-reared monarch carcasses under camera traps and captured footage of wild harvest mice eating butterflies. She also caught a half dozen mice and offered them monarchs. The mice ate monarchs, typically favoring the abdomen or thorax, high-calorie parts with fewer toxins.
“Many rodent species are likely to have some resistance to cardenolides in monarchs, due to genetic changes at the site where these toxins bind,” said Weinstein. “The Pismo Grove is one of hundreds of western monarch aggregation sites, and it seems likely that, at least in the past, rodents throughout the western monarch range may have supplemented their winter diets with monarchs. If you can handle the cardenolides in a monarch, their bodies are full of fat and offer a pretty good meal.”

Mouse eating an entire monarch butterfly.
This meal will be a lot harder to find, as over 90% of western monarchs have disappeared in the last 40 years. The missing beauties will surely impact the ecosystem that depends on them for food.
Denise Dearing, Distinguished Professor at the U, was senior author of the study. Photos and animations by Sara Weinstein.
Find the study, “Harvest mice (Reithrodontomys megalotis) consume monarch butterflies (Danaus plexippus), in the journal Ecology: https://doi.org/10.1002/ecy.3607
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Biological Data
The Science of Biological Data

Fred Adler
In an age when cross-disciplinary collaboration has become a buzzterm, especially in academia, Fred Adler puts his mathematical models where his mouth is. Multi-disciplinary work—in which academic silos are breached in the search for truth—is the hallmark of what Adler, who has a joint appointment in mathematics and biology, does.
His is the kind of work that will be supported by the new science building recently announced by the College of Science, dedicated to applied and multi-disciplinary work, and where most STEM students at the U will eventually find themselves for a time.
As Director of the Center for Quantitative Biology, Adler and his team have applied their data-driven tool kit to everything from viruses to animal behavior, and from biodiversity to infectious diseases. Who else can claim a lab’s subject models as varied as aphid-tending ants, hantavirus, and the Southern Right Whale off the coast of Argentina?

Math in Nature
The Adler group’s approach to research is driven by basic questions about how biology works. To bring together several threads of research, the lab began a study of rhinoviruses, the most common cause of the common cold, and how they routinely and rapidly change. The study uses mathematical models based on known interactions in the immune system and genetic sequences. “We hope to build detailed evolutionary models of this rapidly change set of viruses,” Adler reports.
He and his team are now looking at cancer in humans. There are, of course, hypotheses of how cancer takes over cells in the body and grows. But too many of these hypotheses are based on assumptions that cells behave as they do with complete information and clever plans for the future instead of the confusing world of a real tissue.
“However useful some of these [current] models are,” says Adler, “they are not based on a realistic assumption.” In fact, a prime contribution of the mathematical modeler is “to make sense of things from the perspective of what you’re modeling.” What access to information does the cell or organism have, is a central, guiding question.

Muskan Walia and Emerson Arehart
Part of how cancer behaviors may be better scientifically “unpacked” is through game theory but expanded over time and space and placed in a context of incomplete information between constituent parts.
Mathematical models, or more accurately, an ensemble of models later aggregated like political polls or weather models to predict the future, may be the answer. “We usually don’t get a simple smoking gun,” says Adler referring to complicated questions in biology, whether developmental, behavioral-ecological, immuno- or micro-biological. “With nine or ten big mathematical models running all the time you have a [more robust] hypothesis,” he says.
“All thinking is done using modeling,” Adler reminds us, “whether it’s through language or, in my case, mathematics.” The strength of the latter is that when mathematical modeling is added to the classical biologist’s models, it is “perfectly explicit about its assumptions. When you do the math right (and we always do), the logic leading from assumptions to conclusions is airtight ‘true.’”
This is important because a mathematical argument can’t be controverted. “If conclusions in biological research are wrong, it’s the assumptions that are wrong,” and the researcher can then pivot on those assumptions.
Modeling of this kind, of course, has proven helpful, most recently, in the study of Sars-CoV-19, the virus that has propelled the world into a pandemic. The coronavirus does not operate in isolation, but with other components through the human immune system.
This kind of work is animated not just by its predictive character using statistics—as in the case of artificial intelligence or machine learning (“We aren’t all cyborgs, yet,” Adler says)—but, it is predictive in a mechanistic sense in that it cares deeply about the more nuanced and open-ended “how,” the foundation of the scientific method.
Adler started out at Harvard as a pure mathematician, but by the time he arrived at Cornell University as a graduate student, he had discovered that he really enjoyed talking and collaborating with biologists. Stanford-based Deborah Gordon, a renowned expert on ants, which as he puts it, “achieve a lot of stuff fairly robustly through simple rules,” was one of them. He also found himself with David Winkler in upstate New York in a bird blind and observing the breeding and offspring-raising behaviors of tree swallows. The complicated models he built based on that research were never published, but Adler was hooked on life sciences.
Whether it’s modeling the lungs of cystic fibrosis patients looking for a transplant, determining that the changesnin Covid-19 are driven not just by mutations in the virus but adaptations of human immune response, or other “bench to bedside” medical science, Fred Adler has found a home in the mechanistic aspects, the “how,” of basic science.
How to synthesize his research over the past thirty years is the next big question. For now he will continue with modeling biological systems, their signaling networks based on the body’s own network of “trust” between components, and determining how those systems are corrupted… and maybe how to fix them.
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Space Plants
The Future of Space travel

Ming Hammond
For humanity to push the boundaries of space exploration, we’re going to need plants to come along for the ride. Not just spinach or potatoes, though—plants can do so much more than just feed us.
“There’s a lot of promise, potential and hope that we can use the tools developed in synthetic biology to solve problems.” says Chemistry Professor Ming Hammond, “not just that you would find in space, but where you have extreme limitation of resources.”

A synthetic garden.
Synthetic biology is a field that engineers biological systems. In this case, the team is looking at plants as potential bio-factories. Every organism naturally produces countless proteins as part of its biological function, so why not engineer a plant to produce, say, a needed medication or a polymer that could be useful in future long-term space exploration missions?
“The benefit is that you can take seeds with you,” Hammond said. “They’re very lightweight. They grow and gain biomass using the CO2 that we breathe out. And if those plants can produce proteins on demand—we know that plants are able to produce anti-viral and anti-cancer antibodies on a large scale.”

LED lights and USB camera.
Synthetic biology is already established on Earth. But translating that same technology to spaceflight requires different considerations. Hammond and her team encountered many of these constraints when adapting their experiment to operate within the small (10cm by 10cm) CubeSat enclosure.
For spaceflight, the team decided to engineer plants to change color as they produced the target protein, and monitor the progress with a camera. It’s an elegant and innovative solution, based on a previously published method, but adapted for the constraints of a cube in space.

Final assembly.
“We had to take something that worked beautifully in the most carefully controlled conditions,” Hammond said, “and get it to work under very harsh and challenging conditions inside the plant cube.”
The plant cube was designed with the forward vision of preparing for plant growth studies on the moon, and is a technology development step towards that goal.
The entire experiment took 10 days and appeared to show successful protein production. The results from the team, including collaborators from NASA Ames and International Space University, were published this year.

10x10cm experiment enclosure.
It takes a lot of time and effort to put equipment in space, and Hammond appreciates the many hours of work that the team has put in. “We are a small but dedicated group of volunteers,” she said. “People worked nonstop to fix last-minute things that came up before launch. I’m just really proud of the effort everyone’s put in.”

SpaceX Falcon 9 rocket.
Hammond and her family traveled to the NASA Kennedy Space Center to watch the Dec. 5, 2019 launch of her experiment, which was nestled within a SpaceX Falcon 9 rocket on a resupply mission to the International Space Station.
“At the launch of my experiment, we had a chance to see Bob Behnken and Doug Hurley, the two astronauts that flew the first manned SpaceX flight on May 30, 2020,” she said. “It was an amazing opportunity to share the launch with my son, (6 years old at the time), and other family members. Of all the things I’ve done in science this, for them, is the one that probably inspires the most interest and awe.”
By Paul Gabrielsen
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Our DNA 2021
OUR DNA Magazine
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Fabulous Fungi
Just below the surface of our world lies the vast, unexplored world of fungi. There are an estimated 5.1 million species of fungi weaved into the soil, water and other living organisms that inhabit our planet. Of those five million species, we’ve identified just over 70,000.
Despite being just beneath (and sometimes on) our fingertips, the fungal world remains more mysterious than the ocean. However, one small, but growing group of scientists is looking to change that. Collecting, identifying and researching, mycologists stand on the frontier of the unique, unexplored world of fungi, but so far, universities have done a terrible job of facilitating that science.
What is Mycology?
Mycology is the study of fungi, their relationships to each other and other organisms and their biological and chemical composition. Those fungi include mycelium, the mass of interwoven hyphae that forms the underlying structure of the fungus, like the root systems of plants. More commonly thought of as representatives of the fungal world are mushrooms, which are simply the meaty, fruiting bodies of the fungus.
To learn more about mycology, I spoke with the University of Utah’s only resident mycologist, [and associate professor of the School of Biological Sciences] Bryn Dentinger. As a field of study, mycology remains far younger than almost every other science. Dentinger noted that “it wasn’t until the 1970s that fungi even got their own kingdom. We’re so far behind other groups of organisms in terms of their baseline documentation that one of our main activities is still just getting out and documenting what’s out in the world.”
There are millions of unidentified fungi, and very few mycologists to find them. Still, even with the very limited knowledge of fungi that we have, some people, who Dentinger calls “mycoevangelists” think that fungi have the potential to solve many of our biggest problems.
Can Fungi Save the World?
Well, maybe.
While further research is necessary to understand whether mushrooms can be used to treat mental and physical health conditions, fungi are already helping us combat the effects of the climate crisis. Dentinger is “excited about some of the products that are being promoted, like the company Ecovative, that’s producing Styrofoam alternatives.”
Ecovative’s line of mycelium products also includes environmentally friendly skincare products, gloves, footwear, backpacks and plant-based meat. With just Ecovative’s products, mycelium already offers alternatives to single-use plastics, fast fashion and animal agriculture, some of the biggest contributors to the climate crisis. Luckily, some of those products are catching on.
Dell famously piloted mycelium packaging back in 2011. Earlier this year, Adidas released a concept shoe made of mycelium-based leather. Hopefully, they’ll continue to grow in popularity as they become more economically viable, and businesses are held to higher environmental standards.
Fungi have the potential to help us mitigate climate change, but they also will help us become more resilient to it. After the 2019 wildfires in California, the Fire Remediation Action Coalition used oyster mushrooms to divert dangerous runoff from sensitive waterways. Wildfires in the west will only worsen, but we can avoid some of their most dangerous effects with fungi.
Worsening wildfire seasons in Utah are, predominantly, due to the longer, drier summers. Drier seasons bring longer droughts, straining the desert’s limited water supply. Currently, the vast majority of Utah’s water is used for agriculture. Mushrooms, which can grow almost anywhere, use far less water than animal agriculture, especially when they’re grown indoors.
If we introduce more locally grown mushrooms in our diets, our food systems will be more resilient to drought and extreme weather events.
Mycology in Academia
Despite all this important work being done by mycologists, Dentinger finds that, at universities, “we often have to pretend to be something else. So, we masquerade ourselves as ecologists, or molecular biologists or geneticists, but really we study fungi.”
Mycologists have a difficult time collaborating with others to go out and identify organisms, especially if they are the sole professional in their department. And, because so many other fields of study have moved on “from having to document their organisms, there’s virtually no funding for that kind of research.”
With all these structural disadvantages to conducting mycological research, we’re at risk of letting the field of mycology fall even further behind. More than just neglected, Dentinger has found that mycologists often face active hostility towards their discipline. Other scientists “look at us and they’re like, ‘What are you doing? It’s not even science.’ I’ve been charged with that.”

Still, Dentinger has forged ahead and has started teaching the first mycology class ever offered at the U. “It’s a 5000-level course, but I would say it functions as an Intro to Mycology course because it has to.” Even seniors studying biology at the U have functionally no understanding of fungi. Without students that have a firm grasp of mycology, and no other mycologists working at the U, there’s nobody at the U for Dentinger to even just “go have a conversation with.”
In this current form of mycology in academia, mycologists are isolated, unable to get funding and misunderstood by other scientists at the university. Dentinger finds it “hard to be the only one here,” which makes sense because scientific progress relies so heavily on collaboration. With more mycologists on staff, they would be able to achieve more than the sum of their individual contributions.
Like the objects of their study, mycologists are misunderstood and hard to find. Yet, the organisms they’ve dedicated their lives to have the potential to be an integral part of combating climate change and making us more climate-resilient.
Rather than continue to neglect such an important field, the U should actively look to become a leader in mycology. Dentinger lamented that he would “love to see a center for mycology at a university, but [it] just doesn’t exist. It never has.” Well, maybe it’s about time that it does.
By Will Shadley
This article first appeared in the Utah Daily Chronicle. You can read about another celebrated fungi expert, SBS alumna HBS’94 Kathleen Treseder, here.