bio-news

Alumni VS Coronavirus

October 14, 2020

Alumni Alert
Randy Rasmussen, PhD'98

SBS alumni Randy Rasmussen is the founder of BioFire Diagnostics which, along with ARUP and other Utah biotech companies, is making a difference in fighting the coronavirus.

Randy Rasmussen, PHD'98

UTAH BIOTECH COMPANIES RALLY TO FIGHT THE CORONAVIRUS

After a new virus, COVID-19 (SARS-CoV-2) was deemed a pandemic by the World Health Organization and then rapidly spread throughout the United States and other countries throughout the world, healthcare professionals and patients alike became vocal about the lack of testing kits available throughout the state and country.

In order to ensure that a greater percentage of the population would have accessibility to testing in the event that it was needed, the Food and Drug Administration announced a series of regulatory changes for laboratories and other diagnostic companies that gave already certified high-complexity laboratories (such as the ones found in hospitals or doctor’s offices) the ability to use their own tests to diagnose COVID-19, instead of the pre-authorized and distributed tests from the CDC.

BIOFIRE CREATED CORONAVIRUS TESTS IN TWO MONTHS

As a result, several Utah biotech companies stepped up to the plate, including Biofire Diagnostics, and it’s sister company BioFire Defense, who created a specific biological test used to help healthcare providers throughout the country screen for the novel virus. Partnering with the Department of Defense on the development of the test, BioFire managed to create the test and have it certified for use in as little as two months, a lightspeed feat just when patients across the world needed one the most.

Biofire

“Part of that [shortened time frame] was because the FDA was amazing. They were so good to work with. My team was sending emails to the FDA in the middle of the night and they were getting responses within minutes. It was super impressive. And so I think that’s why the development time was super-compressed,” says Wade Stevenson, senior vice president of BioFire Diagnostics when discussing the timeline of the BioFire test. “The Department of Defense [also] provided us with some end-targets that supported the product that they wanted and they gave us some funds to help get there. The development work was done by BioFire Defense and then BioFire Diagnostics does most of the manufacturing.”

The BioFire test wouldn’t have become a reality without their hundreds of employees coming in to work on the front lines every day. “You can’t do research and diagnostics from home,” laughs Stevenson when asked how the company is handling the process while adhering to the new social distancing guidelines. “You also can’t fit production lines into anyone’s home. So we, as a company, had to take a hard look at who can do their job at home or not. Governor Herbert did claim BioFire an essential business, however.”

Essential, indeed. Throughout the country, and the rest of the world, BioFire’s diagnostic capabilities are capable of saving the lives of thousands of potentially sick patients. In fact, New York City Mayor Bill de Blasio specifically called out another BioFire diagnostic tool, the BioFire FilmArray Respiratory Panels, in his plan to help curb the spread of COVID-19 in New York City. “First thing [healthcare providers] will do, or among the first thing that they will do, is to test you with BioFire,” said de Blasio in a televised March 9th press conference.

De Blasio went on to discuss how providers would use the BioFire respiratory panels to first screen patients for twenty of the most common respiratory viruses to determine if it could be something other than COVID-19. Only after a patient tested negative with the BioFire respiratory test would they be tested for COVID-19, which could save hundreds of tests for those who are likely positive.

“We will be adding COVID-19 to the [respiratory label] but that will take a few more months of development,” says Stevenson. “[When that is added] that will change the game because you can rule out COVID-19 right along with the 20 other cases of respiratory infection.”

Though the FilmArray respiratory panels are already available for purchase, the initial batch of BioFire’s COVID-19 tests was sent to the Department of Defense in mid-March. The company expects to have the test available on a clinical basis around the third week of April.

ARUP LABORATORIES PROVIDES TESTING CAPABILITIES TO UTAHNS

Additionally, to further help meet the need of sick Utahns, ARUP Laboratories, a nonprofit enterprise of the University of Utah, was one of the first non-public health laboratories to offer COVID-19 testing when the pandemic first hit.

ARUP Labs

“ARUP began working with an outside manufacturing partner back in January.  As soon as the FDA issued their guidance in late February, ARUP was able to complete the validation of the test, and we began running tests on March 11,” says Brian Jackson, official spokesperson for ARUP Laboratories.

Between March 11-27th ARUP Laboratories revved up their testing capacity to run 2,400 tests per day. However, in order to preserve both testing capacity and rapid result delivery, ARUP is focusing initial testing efforts on Utah, and as of late March is not offering COVID-19 testing to hospitals outside of the state.

In an online press release, Sherrie Perkins, MD, PHD, and CEO at ARUP says that ARUP has faced challenges in sourcing the needed reagents and other supplies needed to run these tests at scale. And they aren’t the only ones, though BioFire manufactures their own reagents, they too are worried about meeting the demand for their products.

“Demand for the tests is going to be much greater than our ability to provide them,” says Stevenson. “We will very likely launch [the clinical COVID-19 test] under an allocation where we can only fill a [certain number of orders.]” And that’s a problem echoed throughout the entire diagnostic industry.

OTHER COMPANY SUPPORT AGAINST COVID-19

Though the lack of reagents is causing some uneasiness for healthcare providers and biotech companies throughout the country, there are a few other companies throughout Utah who are doing anything and everything they can to normalize the situation as much as possible.

On March 20th, Chris Gibson, CEO of the Salt Lake-based biotech powerhouse, Recursion Pharmaceuticals announced in a series of tweets that they would be partnering with a local “BioSafety Level 3” facility to do a series of experiments on “compounds and their efficacy against COVID-19.”

The Recursion team promised to share any discoveries with the scientific community and Gibson confirmed that the company would not be seeking profit on any discoveries that might be made. But it’s not just the biotech companies throughout Utah rallying around the doctors, nurses, and patients fighting on the front lines. In true tech-community spirit, the companies who make up the Silicon Slopes are working hard to do their part, as well.

In a town hall meeting just days after Gov. Herbert first put the guidelines in place in early March, Silicon Slopes members set up a community relief fund designed to help those in need. They plan to use their allocated funds throughout Utah to fund things like additional FDA approved tests for Utahns, the aquisition of medical supplies for healthcare and nonprofit workers, as well as additional public health and K-12 education efforts.

“One part of Silicon Slopes’ mission is to serve,” says Clint Betts, executive director for Silicon Slopes. “COVID-19 impacts all of us, so it’s important that we all play a role as we address this issue. By pooling our collective resources we’ll be able to come out of this in a lot better position than if we operated in our own siloes.”

Other tech companies in the area, such as Podium, are taking a more targeted approach to help restaurants who have been severely affected by the pandemic. In mid March, the Podium team released their “Text To Takeout” software that allows customers to directly text local restaurants to place, purchase, and pick up their orders. The software makes the process as safe as possible for all parties involved, which provides comfort to customers in a time of uncertainty.

But that’s not all. Other companies like Avii have offered their tax accounting software services to small businesses for free, Woodside Homes announced that they would be collecting PPE for healthcare workers, Nav is offering their expertise with small business finances to those in need, Walker Edison donated over 500 desks to students and workers now forced to work from home, Nearmap is offering their digital software to governments at no cost in order to help them plan COVID-19 relief, and Solutionreach came up with an innovative way to streamline the doctor/patient communication process. And this was all just within the last month.

“We recognize there is a lot of information circulating around COVID-19 and many healthcare organizations are left with no solution to reach out to their patients in a timely fashion with the proper information,” says Solutionreach CEO, Josh Weiner. “Allowing free use of our emergency messaging is just one small way we can continue to support the healthcare community during the COVID-19 situation.”

As the news continues to fill with depressing stories of grief, poverty, and a collapsing system, it’s so important to remember the companies, whether they be biotech or otherwise, who are putting everything into making this situation a little bit better for the rest of us. “There are so many stories of private companies that have approached us and offered their help,” says Betts. “Utah really is going to be a case study for how both the private and public sector can make a difference for the communities they serve.”

 

 - by Kelsie Foreman, in Utah Business Magazine, April 13, 2020

 

Steve Mimnaugh

October 1, 2020

Steve Mimnaugh and Jay Johnson

Most people get to live one life. So far, Steve Mimnaugh has lived at least three.

"I was always the new kid on the block," he says. From Seattle to Spokane, Washington, and from Wallace, Idaho where his father worked as a mining engineer, to Kearns, Utah, to survive Mimnaugh tacked through life as an extrovert, ending up in student government. His extroversion served him well as this biology alumnus advanced into a spirited life as an emergency physician, member of a rock-and-roll band and co-founder of the innovative and celebrated 'SPLORE (Special Populations Learning Outdoor Recreation and Education), a nonprofit founded in 1978 and dedicated to getting folks with disabilities out into white water rafting and other outdoor sports.

Diverse interests, especially as a young person, can make it difficult to get one’s footing. Such was the case for Mimnaugh, at least at the University of Utah where he moved into research during his undergraduate years, started a PhD, and haltingly applied to medical school three alternating years before being admitted to the U’s. There he was also elected class president. The deviations in his academic career seem to have had more to do with his personality rather than any kind of deficiency. In short, this self-described "granola cruncher" has been in a high evolutionary state his entire life, seemingly barreling through whole epochs in record, breathless time.

On the Green River, Desolation Canyon

Being a biologist, evolution tracks well with Mimnaugh's start-and-stop, somewhat circuitous path. His impetus has always been the need to adapt to a changing environment whether it be particularly onerous (sometimes bizarre) medical emergencies in critical care, securing an audience for the fledgling band The Disgusting Brothers, or raising funds to execute outdoor recreation geared toward those with disabilities. Sometimes all three lives would overlap if not converge, but his time at the School of Biological Sciences was always propulsive with associations that included future Nobel Prize laureate Mario Capecchi who was on Mimnaugh’s graduate committee and especially mammalogist and anatomist Stephen Durrant who hired Mimnaugh as a Teaching Assistant. Even so, he says, “I was not driven by [the idea of] nebulous [research] problems to work on.” Neither did he groove on all the isolation of the lab while working endlessly, it seemed, on thin-layer chromatography, mammalian cell cultures, transmembrane ion transport, and THC as an anticonvulsant. Medical school was the answer.

His experiences as an ER physician, most recently at St. Mark's Hospital in Salt Lake City, was perfect for a restless soul who needed variety. It was also a deeply humbling experience, faced as he was regularly with society's most vulnerable populations and some of the, potentially, most humiliating circumstances a person might find themselves in at four o’clock in the morning. “I was no one's doctor, but everyone's doctor,” he says. This included physician to patients with complications of acute alcohol intoxication or to someone suffering from sequestration of rectal foreign bodies. “I got a reputation,” he said, for handling emergencies that required discretion and empathy as much as medical expertise. He also developed a reputation for a bedside manner that had a way of grounding each patient having a traumatic experience back into the collective story that is both familiar and deeply human.

Steve Mimnaugh, 1970s, While in medical school. Other founding members of the band include two other UofU alumni: Curt Crowther, BS'72, MBA'81 and Sam Falsone, BS'74.

While coy about comparing ER work with what soldiers go through in war, he admits to suffering from a kind of PTSD that he’s had to deal with after 35 years. “I never go to sleep without having bad dreams,” he says. Writing about his experiences, now that he’s retired, has helped, and based on a cursory reading of excerpts from his nonfiction manuscript subtitled “Behind the ER Curtain,” the arc and tone of his recounting is both hilarious and touching, deeply informed by science, especially the way evolution plays out in culture and our everyday perceptions of ourselves and of each other. It’s a narrative that promises to do for the reader what Dr. Mimnaugh has regularly done for a broad spectrum of “everyman” patient: it’s okay; we’re all in this together.

It is no surprise that Mimnaugh has a counterweight—more than one, actually—to the intensity of his professional career wearing a stethoscope. As an avid river-runner in the 1970s, he was approached by recreational therapist Martha Ham who explained that there was to date no codified way of getting people with disabilities like cerebral palsy, or spinal cord-injured clients who can't walk, swim, thermoregulate, or apply their own sunscreen safely down a river so that they could enjoy one of the greatest assets of living in Utah: the out-of-doors. Together they founded ‘SPLORE, which, he says, would not have been possible but for the work and love of thousands of volunteers who seemed to benefit as much from what was often a peak experience for them as 'SPLORE's clients. Both Mimnaugh’s life as a musician in an irreverent but beloved Disgusting Brothers Band and his charitable work are symbiotic. The Band whose sound has the passion of an acoustic campfire concert on a whitewater river trip—electrified and amplified--regularly plays its 60/70s favorites for fundraisers, benefiting organizations like Utah’s Hogle Zoo, the AIDS Foundation as well as, back in the day, ‘SPLORE.

The group proceeded to acquire coveted commercial permits on Uinta-Wasatch-Cache National Forest land, as well as for sections of the Colorado and Green Rivers, permits that continue to be the backbone to the services still provided. “It was such an amazing thing,” he recalls referring to his clients with disabilities, “the excitement, awe and wonder… the laughs. They’re out there in the big wide world, not just group homes.” After forty years, eventually bringing 5,000 constituents per year into the wilderness, ‘SPLORE merged with the National Ability Center located in Park City but not before Governor Scott Matheson awarded Mimnaugh and his disgusting brothers who had joined the cause the Governor’s Golden Key Award.

Retirement for Mimnaugh seems to be wearing well for him. He recently married his long-time partner, Jay Johnson, an oncology certified nurse at Huntsman Cancer Institute. And his reading list these days ranges from Margaret Atwood’s The Testaments to the poetry of Mary Karr; and from Rituals for Finding Meaning by Sasha Sagan, daughter of the late science celeb Carl Sagan, to the cultural critique of Dave Rubin’s controversial Don't Burn This Book: Thinking for Yourself in an Age of Unreason. Then there’s Jared Diamond’s trans-disciplinary non-fiction Guns, Germs & Steel followed by his Collapse and Upheaval. “The universe is 13.8 billion years old,” this Disgusting Brother on the bass and rhythm guitar (as well as vocals) muses, referencing Diamond: “We're here, and in a blink of the eye we're gone."

But this much is certain, he concludes. “We’re good at celebrating stuff.” Perhaps that’s the embedded engine in Steve Mimnaugh for living multiple lives. You need more than one life to celebrate all of it.


By David Pace and Mathew Crawley

George Elliott

September 23, 2020

"Always be open to unforeseen possibilities and opportunities; never be afraid to fail, and learn from your failures," says George Elliott (PhD'81). "Don’t get bogged down in a very narrow line of pursuit—the broader your knowledge is the more creative and successful a problem-solver you will be." That's great advice to U Biology students today. And it seems to have been the advice Elliott himself followed back in the day when he was at the U, following his sojourn at University of California, San Diego where he earned his bachelor's.

“My graduate career began in 1973,” says Elliott who with his wife Lissa resides in Virginia. “I was one of only two students accepted into the molecular/cellular/genetics part of the Biology Department that had been newly constructed by K. Gordon Lark. Gordon had hired a dozen or more new professors, mostly young and engaged in a potpourri of cutting edge, exciting research.”

Elliott retired from the United States Patent and Trademark Office (USPTO) in 2016 following an auspicious career as, first, a patent examiner, manager and Group Director of the Tech Center responsible for biotechnology and pharmaceutical patent examination, and finally as Deputy Chief Policy Officer for Operations in the Office of Policy and International Affairs.

Stationed in Virginia, Elliott coordinated operations of approximately 45 attorneys and 55 admin and program staff responsible for advising U.S. Government on Intellectual Property matters and representing the U.S. government in IP-related international organizations and negotiations around the world. The Office of the Administrator for Policy and International Affairs at USPTO assists the Under Secretary of Commerce for Intellectual Property and Director of the U.S. Patent and Trademark Office in advising the President, through the Secretary of Commerce, and Federal agencies on domestic and international IP issues as well as on United States treaty obligations.

Elliott’s experience at the University of Utah was formative across the board. While at the U, he chose to work with Marty Rechsteiner, now Distinguished Professor Emeritus in Biochemistry, who was continually coming up with new ways to look at intracellular small and large molecule metabolism. “The lessons I learned working with Marty and in my interactions with [SBS faculty] Toto Olivera, Mario Capecchi, Dana Carroll, Bill Gray and others, stayed with me for the rest of my career, whether in research or at the Patent and Trademark Office.”

With respect to COVID-19, Elliott is reassuring to students who are faced with what seems an unprecedented time during their academic careers. "It will pass, eventually, but everybody should take it seriously," he remarks. "The idea that younger people are somehow in less danger is being proven less and less true all the time. And nobody should think it is only about protecting themselves—it’s all about creating situations where the virus is spread. But students should know that—they just need to act on their knowledge."

George Elliott is more than grateful for his own experience at the U. He is also one of several alumni who have established a mechanism of estate giving to benefit the School of Biological Sciences. When asked why he has made a gift of this kind, he says, “The education I received while getting my PhD from U Biology was instrumental in providing us with a very enjoyable life together, and we feel it is very important to ensure that the programs that we benefited from can continue to the benefit of those who follow.”

by David Pace

About Planned Giving:

Some planned gifts may yield certain federal tax advantages and can even give you an income throughout your lifetime. The College of Science’s Crimson Legacy Society is designed to recognize those who have made a deep commitment to the future of the School of Biological Sciences through cash or planned gifts at the $50,000 level or above.

Members will be recognized on the Crimson Legacy donor wall and in the College's annual Discover publication. They will also receive special tokens of appreciation in recognition of their support.

Jordan Herman

September 10, 2020

WWJHD?

Few encounter a fer-de-lance snake and walk away unscathed. While working in Costa Rica recent School of Biological Sciences (SBS) graduate Jordan Herman (PhD’20) moved closer to observe a toucan dismembering the green iguana it was having for lunch. When the bird took off and dropped half of it, Herman picked up the iguana’s tail and realized she had nearly stepped on the coiled and camouflaged pit viper at her feet. As the bird returned to finish its meal, Herman stood still, suddenly stuck between an intimidating toucan and the venomous snake. She escaped the dangerous situation by offering up the tail and backing away slowly.

For Herman, this moment earned her “a new appreciation for how cool and terrifying nature can be.”

Herman originally came to the SBS graduate program in 2014 from the University of Minnesota–Twin Cities. Her research has been focused on the fitness consequences that mockingbirds experience when they are co-exploited, how the co-occurring parasites interact with each other, and the roles that host defenses play in these species interactions.

Now a post doctoral fellow in the Clayton-Bush lab, Herman thrives in the outdoors and has always been captivated by birds. While working as a field assistant in the Galapagos Islands off the coast of Ecuador, she became hooked on parasitic nest flies and their endemic bird hosts. This interest, in turn, brought her to Argentina, where she worked on the effects of parasitic nest flies and brood-parasitic cowbirds on their shared host, the chalk-browed mockingbird.

Her passion for the outdoors extends to her adopted home of Utah. When she isn’t backpacking all over the Intermountain West, you can find her spending time in her Salt Lake City garden with her four chickens–Dotty, Penguin, Mungo, and Jerry. Currently, she and her partner Joey have also been treating themselves to sushi takeout from Sapa, a local Asian fusion restaurant where, she says, “you can still order mussel shooters!”

Outside of her research, Herman has also made a lasting impact in SBS where she is grounded in a close-knit community of biologists with wide-ranging research interests. As a mentor, she has soared by offering strong support and advice to those around her. “Jordan’s unwavering sense of self allows her to be a generous mentor,” explains fellow graduate student, Maggie Doolin (Dearing lab), “and one of the most consistent sources of truth and support I’ve encountered anywhere throughout my life. She is one-of-a-kind,” continues Doolin, “and I’m lucky to have had her welcome me to the SBS grad program for all things life and science.” When asked what the best advice Herman herself has received in graduate school, she replies, “Publish early!” You can find Herman’s publications in journals like Ecology and the Journal of Avian Biology.

Clearly an expert in field research, Herman uses her knowledge to give back to her community. “Given the amount of field research, field courses, and outdoor recreation that happens in SBS, our community has a major need for wilderness preparedness,” she says. This need gave rise to Herman’s involvement in developing the biennial subsidized Wilderness First Aid course which is available to students, faculty, and staff in the SBS. A future goal is to expand this program to more personnel across the College of Science.

Jordan Herman, PhD, is truly a force of nature. Next time you’re stuck between an intimidating toucan and a camouflaged pit viper, remember to ask yourself, WWJHD?:  What would Jordan Herman do? The School of Biological Sciences is indebted to Jordan Herman. She will always have a place here among the wide variety of birds and lifelong friends nestled at the base of the Wasatch Mountains.

 

by Andy Sposato

Andy is a graduate student in the Gagnon lab and co-founder of the LGBTQ+ STEM Interest Group in the College of Science.

Carol Blair

August 19, 2020

Carol Blair

Carol Blair (BA’64) is a testament to not only the value of providing research opportunities for undergraduates, but also the transformative experience of working directly with graduate students in the lab.

After she had changed her major from chemistry to the brand new (at the time) field of microbiology, she says, “I was given the opportunity to work as a lab assistant with John Stanton and Joel Dalrymple. (My duties were to capture snakes in the freshwater marshes east of Great Salt Lake, care for and conduct experiments with the snakes in the lab, prepare primary chick embryo cell cultures, assay infectious virus, etc.) John and Joel taught me so much and they enjoyed their work so much, and I enjoyed working with them so much, that I decided I wanted to pursue the academic life for the rest of my career.”

Together they worked with Professor Doug Hill, an expert on arboviruses, who made their research truly meaningful.

Blair, a Salt Lake City native, was an honorary Merit Scholar and was awarded the Principal’s Scholarship as top in her high school class. “The University of Utah was clearly the best for pursuing a degree in science,” following high school, she reports. After graduating with an honors program bachelor’s degree, magna cum laude, in 1964, she moved to Berkeley to enroll in the inaugural doctorate program of the Department of Molecular Biology at the University of California.

From Berkeley she traveled to Ireland to become a postdoctoral researcher at Trinity College, Dublin University, where she was promoted to Lecturer in the Department of Microbiology.

Eleven years after leaving Utah, she returned to the West to study arthropod-borne viruses at Colorado State University in 1975 and has evolved with this area of research ever since. In Colorado State, she served in advancing faculty and administrative positions including Department Head. Today, she is Professor Emerita in the Department of Microbiology, Immunology and Pathology.

Blair has many fond memories of the U: organic chemistry classes with the late Dr. James Sugihara; as a member of the Spurs honorary, ushering at Utah football games (even in the snow) and  at basketball games with Bill "the Hill" McGill, the two-time All-American and top NBA pick credited with creating the jump hook.

“But my research and social activities with John and Joel have to be my favorites,” she says. “I still give a lecture to freshman microbiology students at CSU every fall semester … and the most important advice I give them is: get involved in research in your area of interest, even if you don't plan to pursue a career in research. It will help you understand how to evaluate information and evidence you receive from many sources and expand your learning beyond books and the classroom.

Carol Blair's 1964 honors thesis housed in the University's library holdings

During these days of COVID-19, Blair, not surprisingly, sees things as a virologist. “I like to think I understand what we need to do and why we need to do it to get ahead of this pandemic.” She says she misses the personal, professor-student interactions that have always been the norm. “I won't say we told you so,” she remarks, referring to the professional sector she represents, “but moving forward, our government must be better prepared to recognize this type of infectious disease threat as early as possible and implement all available measures (and we have many) to control it.”

Carol and her husband Patrick Brennan, a Distinguished Professor at CSU, love the outdoors “and all its inhabitants (Carol learned this growing up in rural Utah).” In their retirement, they enjoy hiking and snowshoeing in the local mountains, as well as those in Utah where Blair’s career as a microbiologist and virologist first found fertile soil.

 

 
by David Pace
 

Emily Bates, BS’97

July 30, 2020

It just so happened that the day that the University of Colorado closed down its labs, including Dr. Emily Bates’, she was in labor giving birth to her second child. “I was having conversations with my students about what we needed to do from the hospital bed,” she says. “My husband could not join me for the birth of our son. Our daughter couldn’t meet her brother at the hospital. As soon as it looked like our son and I were healthy, we were sent home.”

Needless to say, the research in Bates’ lab where she is an Associate Professor in the Department of Pediatrics, (Developmental Biology) at the University of Colorado School of Medicine, slowed considerably. “We have not had the opportunity to bring new undergraduate and high school interns into the lab this summer like we usually do, but we have continued to work with one high school student and one undergraduate doing some data analysis from home this summer.”  The lab currently hosts four graduate students as part of the team, but only two people are allowed in the lab at a time.”

At the University of Utah the ACCESS program was key to her success, providing her a cohort of women who were friends and study partners. Established in 1991, ACCESS, a College of Science program now in its 30th year, provides freshmen and transfer students, from a variety of backgrounds, with a scholarship and a supportive path into STEM degrees and careers. For Bates, the program encouraged, she says, “role models to normalize being a woman in science.”

While a scholarship and the rigorous undergraduate research program were main factors in her selection of the School of Biological Sciences, she recalls how fortunate she was to get the right research mentor.  That mentor was Dr. Anthea Letsou in Human Genetics on the University Health campus. “I learned how to test a hypothesis from her, how to use flies to learn about developmental signaling, and how to read a scientific paper.” Perhaps equal to the actual science, Bates learned how to present her research to others. Letsou, she says, “had more confidence in my potential as a scientist than anyone I had met. It was because of her encouragement that I applied to top tier graduate schools.” The whole experience—of the research mentor coupled with ACCESS—gave her confidence and “really jump started my career.”

Photo credit Andrew Silverman

It takes a combination of targeted programs, mentoring and true grit on the part of every student to succeed as Bates did at U Biology. Along the way, she ran cross country for the U her freshman year before turning to marathons (She’s run 18 of them, including as a US representative in Kenya.) Bates credits the unique environment at the U which converged for her, facilitating her graduation in 1997 with a BS and her acceptance to Harvard University for graduate school where she earned her PhD. Returning to Utah, she taught at Brigham Young University for four years before accepting her current position at Colorado.

That was, of course, before COVID-19 reared its head and certainly changed the vector of how she is pursuing her career in pediatrics. She advises students to find a research opportunity with a good mentor and “stick with it,” even during the pandemic. There are skills that can be acquired “at home,” she continues, “that would be useful in labs as soon as they open. For example, learning to critically read a scientific paper, or write programs (in Matlab, R, or Python) to interpret data would be useful in a lot of labs right now.”

In the meantime, she and her family are settling in on the other side of the Rockies from Salt Lake City until a “new normal” makes its appearance. “Luckily,” she says of that singular time in the hospital virtually alone and delivering a child, “my mom had flown in before everything shut down, so she could help us for the first couple of weeks. But other family members have not felt safe flying to visit and meet the newest addition.

“Personally, that has been the hardest part of this pandemic.”

      You can read about the history of the ACCESS program here. 

 
by David Pace
 

Arie Sitthichai Mobley

July 29, 2020

When Arie Sitthichai Mobley (BS'2000) began teaching at a small liberal arts university in a department for undergraduate neuroscience, she says there were many books on stem cells, but they were either too broadly or narrowly focused, or too advanced for an undergraduate course. The lack of an appropriate textbook motivated her to write her own aimed at undergraduate neuroscience students. Her experiences in the lab and classroom coalesced in a clear vision of what undergraduates needed to learn about stem cells and neurogenesis as well as the level of information required. The book is designed to help students appreciate the potential, and understand the limitations of stem cells, while providing a basic knowledge of stem cell physiology.

Science Direct, in a review of the book, reported that "this early graduate level reference describes [neural stem cells'] physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge."

Mobley earned her diploma from South Sevier High School in Monroe, Utah in 1991 and, after graduating with a bachelor's from the School of Biological Sciences, continued at the University of Utah, earning a PhD in neuroscience. Her dissertation was on olfactory sensory neurons of the squid, Lolligungula brevis. (The squid were shipped to her in large bags of water from Galveston, Texas.) Following her graduate work at the U, Mobley did her post doctorate at Yale University where she first developed an interest in adult neurogenesis in disease states. From there she became an assistant professor at Western New England University (WNEU) in Springfield, Massachusetts.

Text book authored by Bio Alumna Arie S. MobleyAfter teaching for four years, she moved to Bar Harbor, Maine, where she is currently associate study director at the independent, nonprofit biomedical research The Jackson Laboratory. The Lab is dedicated to contributing to a future of better health care based on the unique genetic makeup of each individual. Mobley's work is focused on understanding and investigating age-related olfaction deterioration that often precedes neurodegenerative disease.

Her research has been published in journals such as the Journal of Neuroscience, Journal of Comparative Neurology, Trends in Neuroscience, Neurobiology, Aging and PNAS. Dr. Mobley has received several grants including the Ruth Kirstein National Research Service Award (NRSA) at the graduate level under Dr. Mary T. Lucero and at the postdoctoral level under Dr. Charles Greer. She went on to obtain an NIH Small Grant Program (R03) award that was instrumental in beginning her independent research program at WNEU.

"In my position as a Study Director I interface directly with customers to assess customer needs and ensure accurate capture of project specifications in order to develop detailed project plans," Mobley writes on The Jackson Lab's website. "I ensure that plans are successfully tracked and seamlessly executed by ensuring that staff understand and are compliant with all policies and procedures to ensure the most efficient operation, and provide customers with the highest quality scientific service.

"I am uniquely positioned to develop and execute strategic innovation and improvement initiatives, with the objectives to increase capacity, expand product offerings, improve service quality and improve customer experience. I participate in research validation data analysis and support implementation of new techniques and processes."

With her husband Michael, the Mobleys have one daughter.

 

 
by David Pace
 

Clifford Stocks

July 28, 2020

In these uncertain times when “the new normal” of our lives has yet to emerge, SBS alumnus Clifford Stocks (BS’80) opens a window to fresh air on the COVID-19 pandemic. That updraft comes from his scientific orientation and is underscored by his enduring ambition to use his training in biology and beyond to elevate the health of his fellow humans.

“At the end of the day the COVID-19 pandemic is a blip,” he reminds us. “Yes, it caused and will cause many premature deaths and a disruption of lifestyle, and in many cases irreversible economic burden. However, the biomedical complex in the world has become so sophisticated we will have treatment solutions and a vaccine in short order.” He continues on the updraft with a coda:  “And the world will go on as before, but hopefully this pandemic will help people remember that life can be fleeting and to stop and think about what is important to them. And to let those close to them know they are loved.”

It’s a take on this singular time that the world desperately needs right now, a perspective rooted in valuing not only science but the inviolable drive of people to persevere and to assemble ourselves into the collaborative army of our common humanity.

Stocks knows something about perseverance in both the clinical realm and in that of business. Raised in Wyoming before arriving in Salt Lake City, he wrestled in high school and received a scholarship to the University of Utah. “I wrestled four years under coach Marvin Hess,” he says. “This was the only way I could afford to attend college.”

His memories of the U include warm summer nights, trips to the desert—"the heavy focus on the outdoors and exploring the beauty and wonder of Utah”–epitomized by the slickrock country of Moab where Stocks was born. And his time studying biology gave him the opportunity to learn a range of topics in the biological sciences and to determine that he would “dedicate my life's work toward applying biology to help humankind.”

Not surprisingly, that dedication settled in Stocks largely because of important mentors while at the School of Biological Sciences, including Dr. Mario Capecchi, who would later be awarded the Nobel Prize, and whose biochemistry class “inspired in me a love and respect for the power of molecular biology.”

Dr. Robert Vickery, now SBS professor emeritus, was another formative figure for the budding scientist. He “taught evolution and cemented for me the importance of

Clifford & Renee Stocks

recognizing natural selection processes in many biological systems, says Stocks, “including the ability of cancer to form resistance and the power of differentiation in the immune system to combat infection, disease and neoplasms.”

But it was during his senior year as research technician in the laboratory of Seth Pincus, MD in the Department of Immunology at the U’s Medical Center that the young researcher found a home in science. Stocks stayed on there for four years following his graduation from the U in 1980.

After earning an MBA at the University of Chicago where he also did research in molecular genetics and cell biology, Stocks transitioned from the bench to the business side of biotech when he landed his dream position and stayed for 15 years at ICOS Corporation (before it was acquired in 2007 by Lilly and Company). Following other professional stops Stocks founded Seattle-based biotech company OncoResponse, and as CEO has narrowed his broad range of research interests to immuno-oncology. The company currently has several antibodies directed at modulating immunosuppression of the tumor microenvironment in pre-clinical development and is working toward increasing immunotherapy offerings and improving the lives of cancer patients.

“I have always loved rivers and mountains,” says the former wrestler and kayaker, turning to his life outside the world of the lab and of business. “During the '80s and '90s I was part of a world class whitewater kayaking team that conquered several first descents of rivers in North and South America. Today Stocks is an avid fly fisherman which keeps him near rivers in the mountains.  Along with his wife of 25 years, Renee, and their five children they remain focused on academics, athletics and the outdoors.

“Life and career are a journey so make sure to enjoy it and do not let obstacles weigh you down,” he advises. “Oh, and wear your mask to protect others from the spread of COVID-19, and expect others to do same, to protect you and your loved ones.”

The pandemic may be a “blip,” in the organic scheme of things, but it is also, potentially, a transformative opening for inquiry, discovery and resolution. It is an opportunity for all of us, especially, perhaps, for those at the forefront of public health and in the science-inflected imaginations of those like Clifford Stocks.

 
by David Pace, photo by Cassie Redstone
 

Griffin Chure

July 20, 2020

Griffin Chure’s favorite memory of his time at the U was working in Dr. David Blair’s research lab. “During the summers, when class-load was low,” he says, “we characterized the flagellar protein of FIhE, a protein of unknown function." His interactions with Blair and Dr. Sandy Parkinson “firmly set” him on a path towards a career in research.

With a base of confidence provided by mentors in the School of Biological Sciences (SBS), Chure found a natural segue into biophysics, propelled by a course he took from Dr. Saveez Saffarian in 2012. That work “solidified my deep interest in the intersection of biology and physics,” he says, the area in which, after graduation with honors in 2013, he spent his entire graduate career, culminating in 2020 with his PhD in Biochemistry and Molecular Biophysics, at the California Institute of Technology Pasadena.

Griffin Chure

Currently, Chure is a postdoctoral scholar in the Department of Applied Physics at Caltech while next year he will be moving to Stanford University as a National Science Foundation Postdoc Research Fellow to work with Prof. Jonas Cremer. There he will help develop and experimentally test physiologically-grounded mathematical models of bacterial evolution.

Chure’s journey started in the small Green River-side town of Jensen (population 412), seventeen miles from the Colorado state line in Uintah County. “Being raised in rural Utah,” he says, “the option to attend a university with a strong standing in the biological sciences and [to] remain close to family and nature made my choice to attend the U an easy one.” SBS was clearly lucky to get Chure as he continues advancing academically at some of the most prestigious research universities, which like the U, are members of the American Association of Universities, composed of the nation’s top research universities.

His advice to students is to explore science and to do it outside of their comfort level. “It is also important,” he says, “to be sure to be involved in science outside the classroom.” It wasn’t until his graduate studies, he explains, that he was “exposed to the beauty that is probability theory, linear algebra, dynamical systems, and other subfields.” That coupled with extensive training in computer programming “foundationally changed the way I pursue research in biology. The future of biology will be written in the language of mathematics, and quantitative methods should become a central feature of biology education at the U.”

Looking at the larger picture of society and science, Chure is worried that we “live in a time where objective truth and reality seems to be losing its importance with the general populace, even to the point where wearing face coverings has become viewed as a political statement.” Work hard, he says, to convey the science you’re doing to the general public. Even beyond the pandemic, he believes, the only way to fight the erosion of trust in science is to help improve the communication.

Outside of research the recently-minted PhD from Utah has a passion for graphic design and art which dovetails nicely with the work of his wife Bárbara de Araujo Soares who writes Hollywood screenplays. They feel fortunate to have gainful employment during the pandemic. “Going forward, the biggest impact this virus will (hopefully) have on our world,” Chure says, “will be a paradigm shift on how we view and support social causes such as health care, homeless and veteran services, and equitable income support.”

 

 

 
by David Pace