Quaid Harding

From beekeeping to biology, Quaid Harding is looking for a buzz.

Name: Quaid Harding
Major: Biology
Year: Senior
Hometown: Garner, North Carolina

Interests: President of Beekeeping Association, I also like tennis, and billiards

Prior experience with bees?
Before joining the club I didn’t have any experience with bees.

How did you get into beekeeping?
Beekeeping has always been a topic that I was interested in but it wasn't until transferring to the U that I had the opportunity to work with the club and quickly fell in love.

Tell us about the Beekeeping Club.
We have 149 members, 6 Hives, and more than 300,000 bees.

Tell us something most people don’t know about bees.
Not all bees make honey. In fact most do not make honey or even live in a colony.

Tell us about the Pollination Garden.
I wanted to bring more pollinators to campus so I came up with the idea to add a pollinator garden to a landscaping project that was already underway. I had a vision and found a team to help me bring that vision to life.

How has your extracurricular involvement helped your professional skills.
It has helped me get plenty of practice with grant writing, leading a group, facilitating meetings, building interest, networking, and my favorite learning how to care for the bees and even get honey along the way.

To find out more about the University of Utah Beekeeping Club visit https://bit.ly/30xyIVp.

 


 

Connor Morgan

What does a former Student Body President and Biology alum do after graduating from the U? You start by moving to New Hampshire as a boots-on-the-ground organizer for a presidential candidate.

Connor Morgan (BS,2019) has hung up his cap and gown, and his sojourn at the office of the Associated Students of the University of Utah where he served as president to join candidate and former U.S. Naval Reserve officer Pete Buttigieg, the young mayor of South Bend, IN. Buttigieg, the nation’s first openly gay presidential candidate for a major party, is seeking the Democratic nomination and Morgan is there to help him win the race.

“Right now,” says Morgan, “we’re trying to build relationships with those on our turf, recruiting volunteers who support the mayor and training them on how to recruit their own teams of volunteers.” He says he’s not super excited for the New England winter coming up when there will be more door-to-door canvassing in one of the first states where these sorts of outings either get “legs” or don’t. “But I guess, it’s not too much worse than Utah’s.”

Earlier, at the College of Science convocation and commencement, the double-major (biology and political science) baccalaureate says his face was hurting from smiling so much as he assisted in handing out diplomas and shaking thousands of hands. “But I had a great time.”

While he loved ninety-five percent of the job being student body president, he says he’s now “happy to pass on that other five percent of the job. I’m guessing it will be one of the best jobs I’ve ever had working with student leaders, administrators, faculties, in a collaborative approach with many partners around the U.” One of his ambitions during his own 2018 campaign to represent 32,000 students was to move beyond just developing programs and events, but to have his executive team work internally to create a culture of student advocacy.

“I think student government is unique among other student organizations,” he says. “It was incumbent upon us to advocate on behalf of the student body.”  Through this lens, a movie night became a partnership with the resource office at the Student Union among other collaborations that leveraged the full plate of University offerings.

Morgan also worked to have full participation with the University senators, one each from the colleges and the academic advising center. One of the legacy policies that he and his team led was a push to work more closely with the sustainability and facilities team to recommit to the climate commitment initially made by the University at the end of 2008. The goal? For the University of Utah to be a carbon-neutral campus by 2050 if not by 2032 which is the city of Salt Lake’s target. Before leaving office, Morgan helped set up a task force to reassess the way forward, including the money, infrastructure, energy sources, and sustainable living practices to be folded into the curriculum.

Another related initiative, certainly helped by the nation’s raucous and controversial 2016 presidential election, was to increase the vote in the university community. Under his leadership, campus voting booths increased from six in 2016 to twenty during the most recent mid-terms. “Students are more engaged than they have been in recent memory,” he says. "[Many have felt] disenfranchised and not particularly infatuated with the way things are going–more the [general] direction of things, [than just political] parties. They are eager to do something [about it].”

From the beginning campus safety was a priority for Morgan, so it was deeply ironic that just weeks into fall semester, Lauren McCluskey, a college track star, was murdered on campus by a former acquaintance. Morgan recalls that the days following October 23rd were some of the most formative for him, days that were deeply traumatic. “I didn’t know Lauren personally, and I don’t want to appropriate from her friends, but it was very hard to balance being a twenty-one year-old college student myself with doing my part  to console the student body.”

Morgan visited with McCluskey’s friends, helped plan and then attended the vigil. The October 24th event, he says, was “a really good coping mechanism, especially for student athletes.” The biggest lesson from the tragic ordeal for Morgan was when University trustees expressed their gratitude to him for doing his part. “I thought, ‘Why gratitude for showing up?’ The most important things for a leader to do is not to give a speech or to have the best policy ideas, but to show up. I didn’t know that.” He does now, which triggered new policies and a statement embedded in the ubiquitous class syllabi that looks at campus safety through the lens of interpersonal violence.

There are a lot of things that this twenty-two year old U alumnus now knows, and much of it has been shaped by his generation. "We are very different from our parents,” he muses. “In some sense we have more opportunities like having the breadth of the world’s knowledge at our fingertips; the boom in tech and service jobs, for those who are educated enough in these areas; increasing standard of living for many sectors in our generation. But at the same time in some ways we are more limited [by the] challenges.”

He gives the example that for millennials the country has always been at war. “Most of our adult lives have been dealing with the economic shock of 2008/9. We’ve had a much harder time getting first jobs that can provide for the cost of living, to buy a house. We are the first generation that is expected to have a lower life expectancy and make less money than our parents.”

And then there are the political, social and environmental challenges. “The onus on us is to solve problems through science and [by being] civically engaged.” In important ways, he continues, the democratic process isn’t working for his generation and the ones just ahead of his. “An especially prominent concern with many of the people I grew up with … is that we’ve been in a highly educated bubble: the real world isn’t that bubble.”

As a biology graduate, he is deeply concerned about ignorance over science and the scientific method, but “active distrust of science. In the past science has been labeled elitist, [but] now [it’s] being considered by some as 'fake news.'” While he believes society should heed scientific findings, particularly local and global environmental degradation, it is the job of the new generation to better communicate that science to the public. “Yes, peer reviewed communications are critical,” he says, “but equally if not more important is to share those findings with the public.” Morgan had a great model for outreach and working against what he calls the “science deficit model of communication” from Biology professor Nalini Nadkarni. A forest ecologist, Nadkarni knows from working with populations that range from church-goers to the incarcerated that people don’t like to be lectured to. Instead, her model is to engage and integrate communities, with a two-way collaborative, relational and approachable way of sharing data and experiences.

“The everyday person when they hear that ninety-nine percent of scientists believe in [human-induced] global change … will agree [with them].  The first time I took a step back on how people engage with science it was through rose-colored glasses as a sophomore. I thought that everybody believed in science. That wasn’t true. What are some of the issues are in science communication and how we can bridge some of those gaps?"

As a recent graduate, Morgan’s advice to his fellow Utes is to take advantage of the resources the University of Utah offers. For him being a member of the UtahSwimming and Diving Club helped hi find his passion. “Do academics,” he advises, “but remember college is about much more than that.” Aside from being a great de-stresser, the back-stroker (with a little freestyle and individual medley thrown in) says that clubs also provide an “incredible network of friends” to move forward in life.

Headed eventually for law school, a “couple of years from now,” Morgan hopes that with his background in biology he will be “a scientifically informed policy maker,” whether as an officer in a federal department, or working at the local or state level. A run for public office is a possibility. Currently, being in the petri dish of a presidential campaign in the early weeks of a run for a major party nomination will most likely help him make that decision. Speaking as the public servant that he seems destined to be, he remarks that wherever he ends up he “hopes to be able to do whatever is most needed to be useful.”

Bridget Phillips

As one of the University of Utah College of Science's Ambassadors, sophomore Bridget Phillips regularly appears at College events hosting alumni and special guests, and working with faculty and staff to promote science teaching and research at the The University of Utah.

A team member in the Shapiro Lab, she works studying the genetic causes and patterns of variation in the axial skeleton of domestic pigeons.

"Because axial skeleton structure is highly conserved," she says, "understanding skeletal development in pigeons can tell us about the processes that control skeletal development in other animals as well."

A Salt Lake native, Bridget is the recipient of the Ole Jensen Scholarship this year. Because of the scholarship, she says, "I’ve been able to dedicate much more of my time to [research in the Shapiro Lab]. I greatly appreciate and deeply value the scholarship."

Dr. Jensen (BS'72), co-founder of ClearChoice Dental Implant Centers, established an endowment for undergraduate research at the School just last year. He will be at the Retreat this year to receive the 2019 Distinguished Alumni Award.

Bridget's ambition is to attend graduate school and to continue her research in genetics. "By completing a degree in Biology and a minor in mathematics, I hope to be better equipped to study immunology through genetics and bioinformatics research."

Favorite Thing About the UofU:
"I was able to start in a wonderful lab as a first-year and be able to live in Crocker Science House with other like-minded science folks."

Hero:
Thomas Hunt Morgan, who was able to show that chromosomes have a role in heredity.

Little Known Fact:
"Because all 350 breeds are capable of interbreeding to generate genetic crosses, pigeons provide a unique opportunity to identify specific genes involved in many morphological traits."

Associate V.P. for Research

The College of Science is pleased to announce the appointment of Diane Pataki, Ph.D., as the Associate Vice President for Research at the University of Utah, effective April 1st, 2019. She will continue to serve as the Associate Dean for Research in the College of Science through July 1st, 2019.

Dr. Pataki is a Professor in the School of Biological Sciences at the university. Prior to arriving in Utah in 2012, Dr. Pataki received a B.A. in environmental science at Barnard College and an M.S. and Ph.D.at the Duke University Nicholas School of Environment.

Dr. Pataki’s research work is transdisciplinary and has spanned the impacts of climate change on ecosystems, coupled human-natural processes related to urban CO2 emissions, and the role of urban landscaping and forestry in the socioecology of cities. Her lab currently studies human-environment interactions related to urban biodiversity, resource use, & landscape design, and continues to collaborate with social scientists, urban planners, landscape architects, engineers, and local stakeholders to understand the ecological and social consequences of urban landscape change.

In addition to her research, Dr. Pataki served as a faculty member at the University of California, Irvine for 8 years where she was the founding Director of the Center for Environmental Biology and the Steele Burnand Anza Borrego Desert Research Center. She has also served as a Program Director in the National Science Foundation Division of Environmental Biology and a member of the Environmental Protection Agency (EPA) Board of Scientific Counselors.

Dr. Pataki is looking forward to leading efforts across our campus to coordinate and enhance support for research proposal submissions, grantsmanship, and grants management. She will succeed Cynthia Furse, Ph.D., as the new Associate Vice President for Research. Dr. Furse will be transitioning back to full-time teaching and research on July 1st, 2019.

Please join us in thanking Dr. Furse for her exceptional service, and in welcoming Dr. Pataki in her new position.

2019 Churchill Scholar

Cameron Owen of Boise, Idaho, a senior honors student majoring in chemistry and physics and minoring in mathematics, has received the prestigious Churchill Scholarship to study at the University of Cambridge in the United Kingdom. He is one of only 15 students nationally to receive the award this year and is the fourth consecutive Churchill Scholar from the U.

“Cameron’s achievement is a testament to his scientific curiosity and diligence in his undergraduate research,” said Dan Reed, senior vice president for Academic Affairs. “A fourth Churchill Scholarship award in as many years demonstrates the value of undergraduate research and mentorship experiences at the U, and that our students are among the best and brightest in the world.”

The Churchill Scholarship, established in 1963 at the request of Winston Churchill, provides undergraduates with outstanding academic achievement in the science, technology, engineering and math fields the opportunity to complete a one-year master’s program at the University of Cambridge. Students go through a rigorous endorsement process in order to apply, but only after their home institution has been vetted with the Winston Churchill Foundation. The U was added to the foundation in 2014.

Owen, a recipient of a 2018 Barry Goldwater Scholarship, came out of high school with an interest in chemistry. He joined the lab of Peter Armentrout, Distinguished Professor of Chemistry, after hearing about Armentrout’s research in his honors science cohort. While at the U, Owen has published his research and traveled twice to the Netherlands as part of the National Science Foundation Research Experience for Undergraduates program.

Owen and Armentrout, in an ongoing collaborative effort with the Air Force Research Laboratory, are currently studying the activation of methane by metal atoms, particularly gold, in the gas phase. Methane activation, the process of breaking the carbon-hydrogen bond of methane, and subsequent functionalization could eventually be used to convert the enormous amounts of methane from natural and shale gas feedstocks into usable products like methanol or ethane. “I want the activation of methane into liquid fuels and other viable products to be environmentally beneficial and economically advantageous,” Owen said. “Current processes that activate methane are exorbitant in both time and energy.”

At Cambridge, Owen will explore how methane chemically attaches to the surfaces of certain metals. “My project will be purely theoretical,” he said. “But I’ll be able to apply what I’ve learned about certain metals that react with methane in the gas phase to potential catalysts of the future. You can extend those results to better understand the activation of other greenhouse gases in order to create more effective real-world catalysts.”

Owen is looking to continue his work in a doctoral program after his return from Cambridge.

Student Veteran

2018-19 Student Veteran of the Year, Craig L. Hanson 

“When I first came to the U, I didn’t have much discipline or respect for myself or others. I was fortunate enough to find both in the Navy and Marine Corps. After a year I realized I wasn’t quite ready for college even though I was a pretty good student in high school. So, I left.

I was looking for a challenge and became a certified commercial diver and a diver medic. I didn’t know then the combination of deep water and medicine was foreshadowing my future and what would make me who I am today. I joined the Navy in 2010 and became a corpsman. I really engaged with my training and became a distinguished graduate from both the Navy Hospital Corps School in Great Lakes, Illinois, and Field Medical Service School at Camp Pendleton, California.

In 2011, I was assigned to Golf Company “Joker” Second Platoon in 2nd Battalion, 4th Marine Regiment–The Magnificent Bastards–at Camp Pendleton. A month later I was deployed to Afghanistan. My Marines—who I miss all the time—called me “Doc.” We were assigned to an isolated Forward Operating Base in a notoriously dangerous area of operation in the mountainous area of the Helmand Province.

My platoon and I conducted hundreds of dismounted patrols over a seven-month period. In that time, I treated both wounded Marines and countless local nationals-even saving the life of a wounded enemy combatant. And I had the privilege of teaching first aid techniques to Afghan soldiers. Passing my knowledge on to them.

After my two-and-a-half-year tour I realized I had found my passion for medicine. I returned to the U in 2015 and majored in biology with minor in chemistry. Because of my background in emergency medicine, I’ve looked largely at continuing that training and would like to become a trauma surgeon. That being said, I know enough about medicine to know that I’ve barely grazed the surface and am still keeping an open mind about the exact course in medicine I’ll be taking.”

Plant Genomics

QUESTION:

How does RNA decay contribute to gene expression? Could the RNA decay rate be regulated on a molecular basis in order to control genetic traits?

Gene expression is typically measured as messenger RNA (mRNA) abundance, and changes in that abundance are usually attributed to transcription, or synthesis, of mRNA inside the cell. However,
RNA abundance is also influenced by its disposal, or degradation, but how degradation controls RNA abundance is not well understood.

WHO:

“My research uses a plant model, Arabidopsis thaliana, a small mustard plant, and we found that mutants with defects in mRNA decapping proteins experienced abnormal cell growth,” says Leslie Sieburth, Professor of Biological Sciences at the U.

“Our curiosity about why the mutants showed such poor growth led us to discover another mRNA decay enzyme, which we call SOV. We noted in our publication, in 2010, that most eukaryotic genomes encode a very similar protein, including humans,” says Sieburth.

A few years later, in 2013, scientists studying a human disorder called Perlman syndrome discovered that it was caused by mutations in the same gene. The gene, SOV, is known as DIS3L2 in humans.

Perlman syndrome is a genetic disorder associated with overgrowth in the size of the body or a body part of infants. The condition is almost always fatal prior to birth. The disorder has been grouped with Renal cell carcinoma and an increased risk for Wilms tumor.

Starting in 2014, Sieburth investigated how mRNA decapping and SOV/DIS3L2 contribute to decay of all mRNAs using genome-wide approaches.

“A fruitful collaboration with Fred Adler, a professor of biology and mathematics at the U, one of his graduate students, Katrina Johnson, and my postdoc Reed Sorenson, identified the decay rates of more than 17,000 mRNAs, and the contributions from decapping and SOV/DIS3L2,” says Sieburth.

One unexpected discovery was that the mRNAs that decay the fastest use the mRNA decapping pathway. A second discovery was that Arabidopsis mutants lacking an active SOV initiate a feedback pathway where the mRNAs – that are normally degraded by SOV – switch decay pathways, decay faster, and are also transcribed faster.

The results were published in Proceedings of the National Academy of Sciences (PNAS) in 2018.

FUNDING:

Research in the Sieburth laboratory is supported by four National Science Foundation (NSF) grants totaling nearly $2 million. The largest grant, titled, “The role of regulated degradation in controlling cytoplasmic mRNA levels,” focuses on mRNA decay pathways and enzymes, such as SOV. The funding will extend to 2020.

Sieburth recently received a new award funded through NSF’s Early-concept Grants for Exploratory Research (EAGER) program for her project, “Connecting RNA Molecular Kinetics to Developmental Regulation.”

Sieburth employs two undergraduate students, two graduate students – Alex Cummins and
Jessica Vincent – and one postdoctoral fellow, Reed Sorenson.

IMPACT:

Sieburth’s continuing genetic studies could provide new perspectives to fundamental cellular processes that are important in cancer biology and birth defects in humans.

In addition to research, Sieburth also is implementing new curriculum in the School of Biological Sciences. She is currently teaching a new class designed specifically for first-year students. The course, Fundamentals of Biology, is one part of a class sequence that includes two lecture-type classes and two laboratory classes.

“I led a curriculum reform committee, and along with nearly everyone in the School, have spent the past two years designing these courses, reading the literature to identify the instructional methods that have proven to lead to deep learning, and pulling together instructional materials,” says Sieburth. “We are a few months into the class now, and it is exciting to see that the students are engaged and learning.”

FUTURE:

Sieburth has three specific goals for the current NSF study, “The role of regulated degradation in controlling cytoplasmic mRNA levels.”

The first is to assess changes in mRNA decay rates in response to conditions where RNA abundance changes. Usually abundance changes are attributed to transcription, but few scientists have tested the contributions from RNA decay.

The second goal is to understand the feedback that occurs in SOV mutants in Arabidopsis.

Third, she wants to understand the basis for the wide range in mRNA decay rates, where half-life varies between 3.5 minutes and more than 24 hours.

Ryan Watts

Dr. Ryan Watts, BS’00 in Biology, is the CEO and Co-Founder of Denali Therapeutics, a biotechnology company focused on finding treatments and cures for neurodegenerative illnesses, such as Alzheimer’s and Parkinson’s disease.

Watts and his colleagues at Denali are passionate about discovering drug therapies to help over 22 million people across the world who are fighting crippling neurodegenerative illnesses. In fact, Alzheimer’s disease and other age-related neurodegenerative diseases are reaching epidemic proportions. Expressed solely in financial terms, the cost of treating people with Alzheimer’s and other dementias is estimated to exceed $260 billion by 2020 in the U.S. alone.

Watts graduated from Cottonwood High School and came to the University of Utah, reflecting his desire to attend a top-tier research institution. As an undergraduate, Watts received the opportunity to conduct research in the Department of Biology. It was there that Ryan discovered the passion that would determine his career path. Along with his undergraduate research experience, Ryan served as a teaching assistant for Dr. Baldomero “Toto” Olivera and was a Pediatric Technician in Surgery at Primary Children’s Medical Center.

Watts was particularly impacted by his interactions with Dr. Olivera because he recognized how Olivera’s biochemical insights could be translated into treatments for pain. Ryan excelled in the lab and the classroom, and upon graduation was accepted into Stanford University’s Biological Sciences doctoral training program.

At Stanford, Ryan continued to distinguish himself in research and received his Ph.D. in 2004, focusing on the molecules that regulate nervous system development. Afterwards, he accepted a position at Genentech. During his eleven-year tenure there, Watts focused initially on developing therapies for cancer, then switched his attention to neurodegenerative diseases. He led Genentech’s entry into Alzheimer’s disease discovery and drug development, eventually building and leading their newly created Neuroscience Labs.

Watts and a select group of neuroscientists and investors eventually formed a biotech startup named Denali Therapeutics. In contrast to the broad approach of companies like Genentech, Denali would be fully specialized in solving the mystery of neurodegeneration.

Founded in 2015, and headquartered in South San Francisco, Denali Therapeutics has already raised more than $349 million and grown to more than 110 employees. As the name Denali suggests, the treatment and study of neurodegenerative diseases pose significant challenges. These conditions, and therefore the therapies targeting them, are difficult to track. In contrast to cancer, neurodegeneration is both more difficult to target than cancerous tumors and has fewer and less well-defined biomarkers.

Reflecting on his time as a student at the U, Watts has some advice for the current generation of students. “Build connections with the incredible faculty at the U and explore opportunities to get in the research lab as soon as possible. Top notch research universities like the U offer a unique chance to discover original insights as part of your education.”