Andy Thliveris: Remember the Undergrads

Andy Thliveris: 'Remember the Undergrads'

 

In December 2022, Andrew Thliveris BS’83 made a special trip to Salt Lake City with his wife Lauren. They joined the School of Biological Sciences in a belated (due to the pandemic) remembrance of K. Gordon Lark who had passed away more than two-and-a-half years earlier in April 2020.

Vice Chair and Ophthalmology Residency Training Program Director at the University of Wisconsin-Madison’s Department of Ophthalmology and Visual Sciences, Thliveris, until his retirement in September, was also Chief of Ophthalmology at the W.S. Middleton VA and holds the rank of Professor at the School of Medicine in Madison. At the event “Andy” remembered that as an undergraduate he worked in the Lark lab for five years and that Lark had a profound impact on him. “He changed my life,” reported Thliveris whose main message to the faculty and friends who had gathered was “Remember the undergraduate students.”

Thliveris also surprised many by announcing that through his affiliation with the Carl Berg Foundation he had arranged to fully fund the Lark Endowed Chair with a check for $430,000. The Lark fund was established in 2017, followed in July 2022 with a campaign to “re-boot.” The ambition was to achieve the level of endowed professorship through an anonymous, matching donation of $250,000. But with Thliveris’ brokered gift—added to many others from generous individual donors—the K. Gordon Lark Endowment was elevated to the more prestigious level of endowed chair.

'Get this guy under control'

K. Gordon Lark. Credit: Ben Okun

With his characteristic humor, Thliveris was eager to recall his time in Lark’s lab.  He confessed to being that “pesky nerdy undergrad, high-maintenance, known to call Gordon at 11 pm on several occasions, [until] finally, Gordon, then speaking to his post-doc Paul Keim, [said], ‘You’ve got to get this guy under control because I have no idea what the hell I told him last night.’”

Lark wasn’t the only one who mentored, managed and otherwise inspired that “pesky” undergrad. Addressing Nobel laureate and Lark colleague Mario Capecchi who was at the event as well, Thliveris remembered how “you spent many hours with me in your office when you taught biochemistry. I was always in there.” He also recalled Baldomero “Toto” Olivera and his amazing cone snails which would later prove critical in the advance of alternatives to opioid pain relievers, as well as the late Naomi Franklin who helped bring sequencing to Lark’s lab and its occupants.

Regarding Martin “Marty” Rechsteiner, now in the U’s  Spencer Fox Eccles School of Medicine, Thliveris recounted his professor “who on the first day of his class of trembling undergrads told us that if we memorized every word out of this mouth then we might just pass his class.”

Clearly, Thiliveris’ sojourn at the U as an undergraduate where he majored in biology and geology & geophysics, and later attended the U’s medical school where he earned his MD, prepared him well. Following his ophthalmology residency at Wisconsin in 1998, he was a postdoctoral research fellow as a launch to his auspicious 28-year career. After joining the faculty in 2000, he took on the position of Veterans Affairs Hospital service chief and later, in 2014, vice chair of resident education and residency director  — roles he held until his retirement and during which time he trained countless physicians, including many of the department’s own faculty.

'Ball of energy'

At the announcement of his retirement, Thilveris said, “Our residents are beyond amazing, and the dedication from the faculty to our program has made short work for our education team. We have a very proud tradition here and are poised to continue for generations to come.” In hearing the news, many in Wisconsin responded with memories of his meticulous teaching, patience, wisdom, and, of course, his delightful sense of humor.

“I am beyond grateful to Andy for his role in my own training and in my recruitment back to UW-Madison,” said Evan Warner, MD. “His kindness, openness, and genuine concern for each and every colleague, trainee, and staff member has been foundational to our department culture, and it is such a privilege to be a part of it. As residency program director, he has been a ball of energy with so many ideas and such passion for seeking feedback and making things better for the residents.”

Phaco Course Directors Andrew Thliveris, MD, PhD, Sarah Nehls, MD, and Daniel Knoch, MD. (Photo © Andy Manis)

Thliveris will also be remembered for his work as director of the department’s cataract extraction phacoemulsification course. In this three-year progressive course, medical and veterinary ophthalmology residents, UW and visiting medical students, and pre-residency fellows from around the country learn the latest cataract surgical techniques. Daniel Knoch, MD who will assume the role of veterans affairs service chief following Thliveris' retirement recalled how “There are dozens of residents, numerous faculty, and thousands of patients that Andy has helped through his after-hours videos, toolbox approach to surgical teaching, probing questions, and high standards.” Anna Momont, MD who has assumed the role of ophthalmology residency training program director acknowledged that because of Thliveris’ “unwavering dedication to our residents and their training,” is leaving the department nationally recognized and a “highly sought-after residency program.”

'Full steam ahead'

To recognize Thliveris’ lasting legacy, the department dedicated its new Surgical Skills Training Facility in his honor. The new space, which expands the department’s training capacity by providing 10 training pods, each outfitted with state-of-the art equipment, will be instrumental in training the next generation of eyecare specialists. “While the decision to retire was a very emotional one,” says Thliveris, it comforts me greatly to know that I am leaving things in such capable hands. Full steam ahead.”

Whatever Gordon Lark said during those 11 pm phone calls to Andrew Thliveris must have been spectacular. And now with the K. Gordon Lark Endowed Chair poised to announce its first recipient soon, the undergraduate has made sure the legacy of founder of the School of Biological Sciences will continue.

By David Pace

Read more about Dr. Thliveris' retirement at UW-Madison website from which some of this article and photos were taken.

A warming climate could make cities even less hospitable to wild mammals

urban wildlife In a Warming Climate

 

Human-driven climate change could worsen the effects of urbanization on native wildlife, suggests new research based on analyses of data recorded by 725  trail cameras set up in and around 20 North America cities, including Utah’s urban areas along the Wasatch Front.

 

Austin Green, Postdoctoral Fellow in the Science Research Initiative. Camera trap photo above credit: Austin Green.

The main finding was that urbanization’s negative effects on wildlife are tougher on larger-bodied animals and are worse in the less vegetated cities in drier regions, such as Phoenix and Salt Lake City, according to University of Utah wildlife biologist Austin Green, one of the study’s many coauthors.

“Those cities that don’t have as much rainfall have higher average temperatures, the effects that they had on wildlife were greater than in cooler and wetter cities,” Green says.

These findings are based on thousands of photos of wild animals, namely 37 species of native mammals that live in or near cities, ranging from squirrels to black bears. The images were recorded by motion-triggered camera traps operating in the summer of 2019 in places used for outdoor recreation within cities and up to two kilometers beyond the urbanized boundary. To ensure privacy, images of people were automatically deleted by the program that uploaded the photos, according to Green who is aa postdoctoral fellow in the College of Sciences' Science Research Initiative.

Led by Arizona State University biologist Jeffrey Haight, the study published Monday in the journal Nature Ecology & Evolution.

Haight and collaborators from around the country analyzed data from 725 camera traps to assess the composition of native mammal communities and the relative occupancy of each species. In partnership with the Urban Wildlife Information Network, the team covered Salt Lake City, Chicago, Los Angeles, San Francisco Bay Area, Atlanta and Austin and Edmonton in Canada and 13 other cities in the course of some 20,000 camera days.

Read the full article by Brian Maffly in @TheU.

More about this research from the New York Times.

Why Scientists Haven’t Solved the Mystery of the OMG Particle

Solving The Mystery Of The 'OMG Particle'

 

Below the snow-covered peaks of the Andes Mountains, among scattered rocks and the scrub of prairie bushes, there sits at this very moment a 12-ton polyethylene tank holding 3,000 gallons of pure water.

 

All around it, spread out in every direction over an area nearly the size of Rhode Island, are 1,599 more such tanks, each identical to the first. These lonely sentinels have their eyes on the sky, patiently observing what human eyes cannot in the hopes of solving a mystery that began on another continent and more than three decades prior — a mystery that started with the Oh-My-God event.

It was the night of October 15, 1991. The University of Utah had set up an experimental observatory called the Fly's Eye in the isolation of Dugway Proving Ground, a sprawling 800,000-acre tract of land used by the U.S. Army to test biological and chemical weapons since the 1940s. On that night the Fly's Eye detected something called an air shower, a miles-long explosion of streaming particles invisible to the human eye and caused by high-energy interactions in the upper atmosphere. Each of the telescope’s detectors were designed to point at a different part of the field of view, in a similar way to insects’ compound eyes. It was this that earned the telescope its name. “We were hoping we might pick up something really unusual,” says David Kieda at the University of Utah, who worked on the telescope at the time. (Read more about the Fly's Eye Array here.)

Scientists looked at the data they'd collected and worked backward to deduce the properties of the space-borne particle that led to the air shower. The results weren't just shocking — they were thought to be impossible. They called their discovery the Oh-My-God particle.

While the Oh-My-God particle still remains the most energetic cosmic ray ever detected, a handful of others in the off-the-scales range have been observed in the years since, confirming that it wasn't a miscalculation or instrumentation failure, but in fact a real event. This is why 1,600 giant water-filled tanks have been installed in a grid formation across 3,000 square kilometers of the arid Mendoza region of Argentina. These are the specialized detectors of the Pierre Auger Observatory, forming an array designed to capture evidence of other extremely high-energy cosmic rays. "The quest for identifying the sources of the most energetic particles in the Universe continues," says Carsten Rott, chair of the Department of Physics & Astronomy at the U. "[But] not only at the Auger detector in Argentina, but also right here in Utah with the Telescope Array experiment."

 

Read the full story by DAVID ROSSIAKY in Slash Gear.

Volcanism That Drove Ancient Global Warming

Volcanism that Drove ANCIENT Global Warming

Geological evidence extracted from the floor of the Atlantic Ocean affirms a long-standing theory that greenhouse gas emissions associated with volcanism drove catastrophic climate change 56 million years ago.

A new study by an international team of scientists—including University of Utah geologists—examined hundreds of core samples in search of clues to what drove rapid warming that triggered the deep sea die-off marking the transition from the Paleocene to the Eocene epoch. A paper published this month concludes that large volumes of methane—a potent greenhouse gas—escaped from hydrothermal vents on the ocean floor during a period of intense volcanic activity.

Around the time the Americas and Europe started spreading apart to form the North Atlantic, Earth’s temperatures spiked by 5 degree Celsius and ocean chemistry changed during a 200,000-year period known as the Paleocene-Eocene Thermal Maximum, or PETM. This resulted in a major extinction event that wiped out a lot of deep marine life and accelerated evolution among terrestrial creatures, with mammal species becoming more diverse.

Ancient analogue for today’s climate change

“This article provides evidence for hydrothermal venting playing a major role in the global warming event that happened during the PETM by showing vents in the North Atlantic erupted in very shallow water and coincided with the onset of the PETM,” said Sarah Lambart, a U professor of geology and geophysics. “While their origins are different, the PETM presents similarities with global warming today in that the sediments that were heated were very rich in hydrocarbons. So this event can be used as a natural analogue for how the Earth system responds to the rapid burning of fossil fuels.”

She noted that today’s anthropogenic climate change is 100 times faster than what transpired at the end of the Paleocene.

Scientists have long believed the PETM was triggered by rapid and massive releases of carbon dioxide (CO2) and methane (CH4) into the atmosphere from geological sources.

Methane is a far more powerful greenhouse gas than carbon dioxide, although it eventually breaks down in the atmosphere. Over short time frames, methane could have a major impact on the climate, and the scientific team thinks that might be the case with the PETM, which coincided with the volcanic-driven continental breakup that created the Atlantic.

 

To read the full story by Brian Maffly in @TheU.

Loudest Stadium … according to science

Geoscience and football meet at Rice-Eccles

 

U geoscientists are now measuring the actual seismic impact of Big Time college football on the Salt Lake City campus and live tweeting the measurements during games, starting with Thursday’s Florida-Utah matchup.

Ahead of the Utes’ season opener, seismologist and Utah season ticket holder Jamie Farrell installed the seismometer in the Rice-Eccles Stadium to measure and record Earth shaking associated with fans’ response to on-field action during the Utes’ home games.

“We’re going to try to convert the amount of energy that gets released either over an entire game or if there’s a big event, where it shakes a lot, and try to convert that into equivalent magnitude, how much energy is put into the ground,” Farrell said. “But if not, we can compare different things, like when the team ran into the stadium, when we scored our first touchdown or this was a third-down stomp.”

Farrell is an associate research professor in the Department of Geology and Geophysics, where he helps oversee the U of U Seismograph Stations, or UUSS. He is an expert in the use of seismic waves to characterize the Earth’s crust, with a particular focus on the volcanism under Yellostone Park.

 

Find out the results and read the rest of the story by Brian Maffly in @theU.
Read more coverage of this story at KSL-TV.

Finalists vie for historic $1.5M Wilkes Climate Prize

Finalists vie for historic $1.5M Wilkes Climate Prize

 

A protein-rich bean that evades agricultural emissions? Pepto for cows? Connect the ocean to the power grid? Smart windows on every building? Trees that reduce poverty and save the rainforest?

 

We need bold thinkers with audacious ideas to help mitigate the impacts of climate change. Often, the most unconventional projects have the hardest time getting funding. At $1.5 million, the Wilkes Center Climate Prizeat the University of Utah is one of the largest university-affiliate climate awards in the world. The Wilkes Center for Climate Science and Policy in the U’s College of Science will administer the prize, funded by a cross-section of Utah-based organizations and industries. A panel of respected climate leaders reviewed 77 international proposals and identified five projects representing the most innovative ideas to address the impacts of climate change. The winner of the historic prize will be announced on Sept. 22, 2023.

“I applaud the inspiring and innovative ideas of all five finalists,” said Peter Trapa, dean of the College of Science. “This out-of-the-box, entrepreneurial thinking is precisely what the Wilkes Center is designed to foster. I am excited for the winning organization to  use the prize funds to advance meaningful solutions to the problems posed by a changing climate.”

Learn more about the Wilkes Climate Prize finalists! Note that all assertions are from presentations made at the Wilkes Climate Summit in May 2023.

Which project would you vote for? Read summaries of all five.

Matthew Sigman Receives The 2023 Patai-Rapport Lecture Award

Patai-Rapport Lecture: Matt Sigman

 

He received this award at the 22nd European Symposium on Organic Chemistry. According to www.esoc2023.org, the "European Symposium of Organic Chemistry" includes key scientific events that since the 70s have been organized every two years in different cities in Europe. Every edition had an attractive multidisciplinary scope and worldwide attendance from industry and academia.

The Patai - Rappoport Lecture celebrates the vision of Saul Patai and Zvi Rappoport in creating and advancing the book series "The Chemistry of Functional Groups," providing chemists with a highly valuable tool for advancing their research. Founded in 1964, the series has grown to over 150 volumes with 1,750 chapters on a wide range of functional groups and compound classes, contributed by expert authors from more than 50 countries. The current chief editor of the series is Professor Ilan Marek. The Patai – Rappoport Lecture is supported by John Wiley & Sons.

Read more about Sigman Research Group.

Originally posted at chem.utah.edu

Clean Energy Beneath our Feet

NYT: Clean Evergy beneath our feet

 

“No one else is willing to take the risks we can take,” said Joseph Moore, a University of Utah geologist who leads FORGE.

 

In a sagebrush valley full of wind turbines and solar panels in western Utah, Tim Latimer gazed up at a very different device he believes could be just as powerful for fighting climate change — maybe even more.

It was a drilling rig, of all things, transplanted from the oil fields of North Dakota. But the softly whirring rig wasn’t searching for fossil fuels. It was drilling for heat.

Mr. Latimer’s company, Fervo Energy, is part of an ambitious effort to unlock vast amounts of geothermal energy from Earth’s hot interior, a source of renewable power that could help displace fossil fuels that are dangerously warming the planet.

“There’s a virtually unlimited resource down there if we can get at it,” said Mr. Latimer. “Geothermal doesn’t use much land, it doesn’t produce emissions, it can complement wind and solar power. Everyone who looks into it gets obsessed with it.”

Traditional geothermal plants, which have existed for decades, work by tapping natural hot water reservoirs underground to power turbines that can generate electricity 24 hours a day. Few sites have the right conditions for this, however, so geothermal only produces 0.4 percent of America’s electricity currently.

But hot, dry rocks lie below the surface everywhere on the planet. And by using advanced drilling techniques developed by the oil and gas industry, some experts think it’s possible to tap that larger store of heat and create geothermal energy almost anywhere. The potential is enormous: The Energy Department estimates there’s enough energy in those rocks to power the entire country five times over and has launched a major push to develop technologies to harvest that heat.

Dozens of geothermal companies have emerged with ideas.

 

Read the full article byBrad Plumer in the New York Times.

Spiders and Plants, Richard Clark

how spider mites quickly evolve resistance to toxins

Although mites are arthropod-like insects, they have eight legs and are more closely related to ticks, spiders and scorpions. The two-spotted spider mite is tiny, hardly half a millimeter long, and is named for the pair of black spots on either side of its partially translucent body. These spots are actually the digestive contents of its gut.

 

A ubiquitous inhabitant of greenhouses across the United States, it is equipped with needlelike mouthparts that both pierce and suck nutrients from leaves, leaving them a desiccated shell and killing the plant. They also deposit a silky webbing across the host plant, hence the second half of this mite’s common name.

“Arthropod pests have been responsible for historic famines and food shortages, and continue to impact human welfare today by reducing crop yields. So there’s been an interest in developing plant varieties which are more resistant to insects or mites,” said Clark, a professor in the School of Biological Sciences.

Working with then-U graduate student and lead author Meiyuan Ji, as well as colleagues from Belgium, Clark’s lab identified a mechanism by which spider mites “express” genes involved in the detoxification [inactivation] of xenobiotics, as is commonly observed in pesticide-resistant spider mites, according to research published this month. The findings could help scientists develop more effective ways to control this pest.

Read the full story by Brian Maffly on this research in @TheU.