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Academia in Action

Academia in Action: Mentoring, patenting and learning

 

Universities primarily exist to educate students and add to the existing knowledge base. University of Utah chemistry professor Vahe Bandarian and former graduate student Karsten Eastman were able to balance both those goals while pursuing patenting on a new invention that resulted from their research.

 

Bandarian, professor of chemistry and associate dean in the College of Science, researches enzymes whose function is unknown but give the cell some sort of advantage. “We basically pick a class of enzymes or a class of molecules and then look at every level from how they're made, what the actual enzyme does, all the way down to the atomic level,” Bandarian says. “We are a lot more focused on discovering new and cool chemistry and enzymes.”

When then-graduate student Karsten Eastman joined Bandarian’s lab, Eastman hopped on one of the available projects, and through some serendipity Eastman and Bandarian realized the enzyme they were studying had the potential to change peptide-based therapeutics.

Typically, enzymes have one job to perform, but this particular enzyme was doing a lot more than normal. “We realized that we might be able to apply this to start making better versions of therapeutics already on the market,” Eastman says. “Once we had this aha moment of, ‘Hey, look, we can actually use this molecular machine to do work on a lot of different things,’ that set everything in motion.”

What they discovered was a way to introduce a better alternative to a disulfide bond. Many peptides and proteins in a human body use these disulfides—or a connection between two sulfur atoms—in their structure, essentially dictating how rigid the structure is. The problem is these disulfides can cause compounds to have a short half-life because the structure is easy to break apart, allowing the body to digest it quickly.

“Now that's great when you're trying to regulate things normally within the body. However, from a therapeutic standpoint, that's a big problem,” Eastman says.

Eastman and Bandarian were able to engineer a process by which an enzyme can install a thioether—sulfur to carbon—bond within a peptide, rather than a disulfide. “It's a much stronger bond. And what that allows us to access is a therapeutic that essentially doesn't have that downside of the short half-life,” Eastman says.

Read the full story on the U's Technology Licensing website.
Watch a video featuring Karsten Eastman on the research at the Utah Life Sciences Summit below.

Our DNA 2023

OUR DNA 2023


Air Currents 2024

The 2024 edition of Air Currents, magazine for the U Department of Atmospheric Sciences

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Synthesis 2024

SRI inaugural cohort, the U in biotech and stories from throughout the College of Science

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Aftermath 2024

The official magazine of the U Department of Mathematics.

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Spectrum 2023

The official magazine of the U Department of Physics & Astronomy.

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Common Ground 2023

The official magazine of the U Department of Mining Engineering.

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Down to Earth 2023

The official magazine of the U Department of Geology & Geophysics.

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Catalyst 2023

The official magazine of the Department of Chemistry at the University of Utah.

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Synthesis 2023

Wilkes Center, Applied Science Project and stories from throughout the merged College.

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Aftermath Summer 2023

Anna Tang Fulbright Scholar, Tommaso de Fernex new chair, Goldwater Scholars, and more.

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Air Currents 2023

Celebrating 75 Years, The Great Salt Lake, Alumni Profiles, and more.

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Spectrum 2022

Explosive neutron stars, Utah meteor, fellows of APS, and more.

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Aftermath 2022

Arctic adventures, moiré magic, Christopher Hacon, and more.

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Our DNA 2022

Chan Yul Yoo, Sarmishta Diraviam Kannan, and more.

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Spectrum 2022

Black Holes, Student Awards, Research Awards, LGBT+ physicists, and more.

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Aftermath 2022

Student awards, Faculty Awards, Fellowships, and more.

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Our DNA 2022

Erik Jorgensen, Mark Nielsen, alumni George Seifert, new faculty, and more.

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Notebook 2022

Student stories, NAS members, alumni George Seifert, and Convocation 2022.

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Discover 2021

Biology, Chemistry, Math, and Physics Research, SRI Update, New Construction.

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Our DNA 2021

Multi-disciplinary research, graduate student success, and more.

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Aftermath 2021

Sound waves, student awards, distinguished alumni, convocation, and more.

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Spectrum 2021

New science building, faculty awards, distinguished alumni, and more.

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Notebook 2021

Student awards, distinguished alumni, convocation, and more.

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Spectrum 2021

Student awards, distinguished alumni, convocation, and more.

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Aftermath 2021

Sound waves, student awards, distinguished alumni, convocation, and more.

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Our DNA 2021

Plant pandemics, birdsong, retiring faculty, and more.

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Discover 2020

Biology, Chemistry, Math, and Physics Research, Overcoming Covid, Lab Safety.

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AfterMath 2020

50 Years of Math, Sea Ice, and Faculty and Staff recognition.

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Our DNA 2020

E-birders, retiring faculty, remote learning, and more.

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Spectrum 2020

3D maps of the Universe, Perovskite Photovoltaics, and Dynamic Structure in HIV.

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Notebook 2020

Convocation, Alumni, Student Success, and Rapid Response Research.

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Our DNA 2020

Stories on Fruit Flies, Forest Futures and Student Success.

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Catalyst 2020

Transition to Virtual, 2020 Convocation, Graduate Spotlights, and Awards.

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Spectrum 2020

Nuclear Medicine, PER Programs, and NSF grant for Quantum Idea Incubator.

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Discover 2019

Science Research Initiative, College Rankings, Commutative Algebra, and more.

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Spectrum 2019

Nuclear Medicine, PER Programs, and NSF grant for Quantum Idea Incubator.

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Notebook 2019

The New Faces of Utah Science, Churchill Scholars, and Convocation 2019.

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Catalyst 2019

Endowed Chairs of Chemistry, Curie Club, and alumnus: Victor Cee.

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Our DNA 2019

Ants of the World, CRISPR Scissors, and Alumni Profile - Nikhil Bhayani.

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Catalyst 2019

Methane-Eating Bacteria, Distinguished Alumni, Student and Alumni profiles.

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Spectrum 2019

Featured: Molecular Motors, Churchill Scholar, Dark Matter, and Black Holes.

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Our DNA 2019

Featured: The Startup Life, Monica Gandhi, Genomic Conflicts, and alumna Jeanne Novak.

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AfterMath 2018

Featured: A Love for Puzzles, Math & Neuroscience, Number Theory, and AMS Fellows.

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Discover 2018

The 2018 Research Report for the College of Science.

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Spectrum 2018

Featured: Dark Matter, Spintronics, Gamma Rays and Improving Physics Teaching.

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Catalyst 2018

Featured: Ming Hammond, Jack & Peg Simons Endowed Professors, Martha Hughes Cannon.

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Southwest Sustainability Innovation Engine

Regional Innovations Engine

University of Utah part of new NSF-funded initiative to ensure regional climate solutions and economic opportunities.


 

The National Science Foundation (NSF) on Monday announced the University of Utah along with six core academic partners will be part of a multi-institutional enterprise to confront the climate challenges facing the desert Southwest and spur economic development in the region.

The effects of climate change are acutely evident in the American Southwest, from the desertification of Utah’s Great Salt Lake to the record-breaking extreme heat in Arizona and the dwindling supply of the Colorado River reaching Nevada.  

NSF Engines: Southwest Sustainability Innovation Engine (SWSIE) will use these challenges to catalyze economic opportunity and seeks to establish the Southwest as a leader in carbon capture, water security and renewable energy and bring high-wage industries to the region. Southwest Sustainability Innovation Engine unites academic, community, nonprofit and industry partners across Arizona, Nevada and Utah that are committed to this goal.

SWSIE is among the first proposals selected by the NSF to establish a Regional Innovation Engine, a first-of-its-kind NSF program to create focused research and technology transfer hubs. The NSF will fund SWSIE’s initial development and growth with $15 million over the next two years. The engine can be renewed for up to 10 years with $160 million in funding available for each Regional Engine.

The U of U’s core academic partners in SWSIE are Arizona State University, who serve as the lead partner of the project, the University of Nevada, Las Vegas, the Desert Research Institute, the Water Research Foundation, SciTech Institute and Maricopa Community Colleges. The team includes over 20 senior personnel including faculty from Atmospheric Sciences, Biological Sciences, Civil and Environmental Engineering, Chemical Engineering, Communications, Electrical and Computer Engineering, Geography, and Geology and Geophysics.  The College of Science's Wilkes Center for Climate Science and Policy is also part of the consortium. 

THE U’S LEADERSHIP TEAM

Brenda Bowen.

At the helm of the U leadership team is Brenda Bowen, co-PI on the SWSIE project and co-lead of the community development working group. Bowen is professor of geology and geophysics, chair of department of atmospheric sciences, and director of the Global Change and Sustainability Center at the U.

“We are so thrilled to have the opportunity to grow academic, industry, and community partnerships that unite Utah, Nevada, and Arizona as we innovate sustainable solutions for water, energy, and carbon,” she says. “This is work that needs to happen, and this award will allow us to align our efforts to maximize the positive impacts across the region.” 

 

 

 

 

 

 

 

 

Read the entire story by Xoel Cardenas, Sr. Communications Specialist.,Office of the Vice President for Research here.

Getting the right image

Getting the right Image

 

New X-ray Instrument keeps up the global-leading high-resolution 3D imaging research in metallurgical engineering at the University of Utah.

^ Jiaqi Jin. ^^ Banner photo above: Jin in front of the XRM-900 in the William Browning building. Credits: Todd Anderson

Assistant Professor of Metallurgical Engineering in the U's Department of Materials Science and Engineering Jiaqi Jin recently took delivery of a new X-ray instrument, the first of its kind.

The acquisition arrived just in time, underscoring Jin's 2023 Freeport-McMoRan, Inc. Career Development Grant from the Society for Mining, Metallurgy & Exploration (SME). The recognitions was for his research expertise, teaching contribution, and service in the mining community. Using X-ray Computed Tomography (CT) in 3D characterization of particulate systems is an important aspect of Jin’s research work. And this newly arrived X-ray instrument will significantly strengthen his capability in mineral processing studies, which also maintains the U's metallurgical engineering program as arguably the best in the country.

In a recent tour of the equipment deployed in December in the Browning Building at the U, Jin explained the history of 3D imaging in the field of mineral processing from its early stages at the flagship university. “In the very beginning, our research group collaborated with the Ford Motor Company,” said Jin. “Some automobile parts were produced by casting, and Ford used micro X-ray CT to image defects (gas holes) inside the parts. We sent our mineral samples to Ford. They [would] scan it, send the image back, then we processed and analyzed them for our mineralogy study.”

In 1996, NSF funding was secured by the department’s Miller group to buy the U’s first instrument of micro X-ray CT. This ARACOR Konoscope had a resolution of the art voxel (pixel in 3D) size imaging 20, 10, and 5 μm. Later, an Xradia-400 micro X-ray CT system was installed by the same group in 2009. (Miller retired in 2023 after 55 years of service at the U.) The micro X-ray CT instrument was also called “X-ray microscopes” (XRM). Inside a big lead box, the source, sample, X-ray optics, and camera are aligned on rails for different magnifications of high-resolution 3D imaging. This Xradia-400 XRM, which will continue to be used for the time being at the Jin lab,has been used to scan samples at the smallest voxel size of 1.8 μm in practice. The Xradia series uses a “two-stage magnification” approach (sealed X-ray tube and an objective magnification detector) to generate a small effective detector pixel but is limited some by low detector efficiency and costly source replacement.

Patent-pending architecture

Now, the new X-ray CT instrument, called the EclipseXRM-900TM, introduces a patent-pending architecture to achieve its breakthrough resolution capabilities, offering both 0.3 μm (300 nm) resolution and the highest resolution for large working distances (large samples). This achievement is enabled by both the minimized source spot size (novel open X-ray tube with state-of-the-art electron optics) and the minimized effective detector pixel size (large pixel count flat panel detector).

Jin has been using X-ray CT to characterize the multiphase particles, which provides important 3D information on mineral liberation, exposure, particle damage, and pore network analysis of packed particle beds such as those encountered in heap leaching or dewatering. This new technology will enable his group to study finer features of minerals and, ultimately, will be more economical in the case of mining for metal extraction with better energy efficiency.

The manufacturer of the equipment, Sigray, Inc., deploys powerful, synchrotron-grade research capabilities to bring to market laboratory X-ray systems. Their products include X-ray absorption spectroscopy, high-resolution X-ray fluorescence 2D elemental imaging and high-resolution X-ray CT for 3D imaging. These research facilities, as with the U’s, are often tasked with 2D or 3D imaging the samples at the best quality and at the fastest acquisition times.

Quantitative information from 3D Images

In the discipline of metallurgical engineering, which recently moved to the College of Science, it’s all about getting the right image. And for Jin’s team, that includes scanning a variety of different samples, such as the porous structures architected by material chemists. These structures are then reconstructed and transformed into 3D digital images to show remarkable contrast and details of the nanopores.

“The important part [of our work] is about image processing and analysis,” said Jin. “Besides the fancy-looking 3D pictures, what quantitative information can you extract out of the scans?”  That's what the past 30 years have been about for the metallurgical engineering team at the U: to develop the expertise and algorithm to run the analysis, “so that they [scans] actually provide value.” The new EclipseXRM-900TM will make that happen more efficiently and more broadly.

 

by David Pace

Coal Miner’s Daughter

Coal miner's Daughter

 

Spotlight on the first woman chair of the Mining Engineering Department’s Industrial Advisory Board — Denee Hayes.

Denee Hayes with her father at the Mining Engineering Department's award ceremony 2023.

“The work I’ve done both within and outside of the mining industry has helped me understand what the outside community thinks about mining,” says Denee Hayes BSME’02. She explains that there is a misunderstanding about how mining contributes to green energy, sustainability and the environment. Through her diverse work experience, she developed the talking points and negotiating skills to be a moderator and mediator between mining and environmental groups. “It really shaped the work that I’m doing today in mining, manufacturing as well as utilities and other sectors.”  

While not on the trajectory of the late Loretta Lynn, whose 1971 Grammy-winning song “Coal Miner’s Daughter (and later, the Academy Award-winning bio-pic starring Sissy Spacek) told the story of the country singer’s upbringing in Butcher Hollow, Kentucky and her elevation into stardom, Hayes’ journey is no less auspicious. In fact, Hayes’ career may end up having a profound impact on the defining issues of our times. Arguably, it already has.  

Hayes was raised in Farmington, NM by parents who owned an oil and gas business. Her father was from Carbon County, Utah and not only worked in oil and gas as well as in mining sales. He also drove a truck for the coal mines in Wyoming. Both of her grandfathers also worked in oil/gas, construction and mining in Utah, New Mexico, and Arizona. Even before high school graduation, Hayes showed an interest in getting a degree in mining engineering. Poised to swoop in, the University of Utah offered a full-ride scholarship and, critically, the industry offered internships and industry experiences starting the summer before she arrived on campus in 1994.  

 

Thought leader 

Since graduation in 2002 Hayes has become a thought leader in the necessary convergence of mining and the new green economy. This, while working for nine years in-house with Utah’s Kennecott Copper until 2020 when she pivoted to private consulting, which she continues to this day.  On the academic side, she was the first woman chair of the Mining Engineering department’s industrial advisory board. 

 The stakes right now in reimagining the mining sector as it relates to a green economy could not be higher. Regarding the climate challenge at large, we really only have one chance to get it right, according to New York Times David Wallace-Wells. In a recent Tanner Humanities Lecture at the U, the climate journalist reported that half of all carbon emissions have come about in just the last 25 years. Even more startling, the weight of that carbon (yes, there are methods of measuring it), is more than the total mass of everything ever built by humans and still standing on earth.  

 Hayes and her colleagues and collaborators may well be up to the herculean task as they look more closely at the complexity of the mining/environment conundrum, and to find allies. “I like the ability to pull together — the interdisciplinary approach — to solving these problems and issues,” she says.  “Diversity of thought and mining engineering gave me the technical knowledge and the language to work between the parties.” She views her training at the U as forging her into a “jack of all trades,” earning a degree that crosses various kinds of engineering — mechanical, civil, electrical — with the pure sciences of physics, chemistry and high-level mathematics. This interdisciplinary approach has threaded through her training and work experience via software development, utilities, manufacturing, architecture, mining engineering, integrated operations, and corporate leadership, all while deploying her signature bridge-building skills.  

 The span between mining and the environmental ethic is not a small one, and it is by dint of Hayes’ experience in a variety of sectors that she has forged her current work as a consultant. “The work I think I did [at Kennecott and elsewhere] gave me a view of two sides, really seeing how the industry has a PR problem and that mining [professionals] have really pitted themselves against environmentalists and other industries, and how we really need to show that if you are pro-green energy you have to be pro-mining.”  

At first blush, such a statement seems counterintuitive, but she continues. “If you think about the trajectory society is currently on “there are ebbs and flows in everything for green energy” whether it’s photovoltaic materials to convert sunlight into electric energy or other sources of renewable energy, like wind and hydro power.  

The greening of America 

To keep up with green economy demands, Hayes explains that the world “will need to mine the same amount of copper between now and 2030/40 as we have in all of humanity,” And that is an example of just one metal. “Because there’s that much copper that goes into those things [i.e., green technologies, coupled] with population growth, even power transmission — from coal or a green energy source —  you still utilize copper and a whole host of other critical minerals within that energy transmission and distribution.”   

Do you rely on a mobile phone? Hayes is quick to remind us that more than half of the periodical table goes into producing and running your cell phone. Furthermore, “anything in the periodic table needs to be mined.” 

The challenge of greening America is not just about extraction of critical metals from new as well as historical mines (known as brownfield sites) which are being re-opened and are using new technologies to re-mine, for example, tailings. It’s also about water use, of particular concern to those of us in the West. Part of building a consensus between two opposing sides is to hold a space for both without papering over reality, on either side.  

“I think that we now have an opportunity to right some of the wrongs of mining in the past and some of the ways that we didn’t understand how we were harming the Earth,” she says, not only referencing Environmental Protection Agency-designated superfund sites of mines but seeing the sector from the view of digital optimization of the entire value chain. These involve standards, both enforced by governmental regulations as well as industry best practices that don’t exist outside the U.S. which is why Americans have relied on questionable extraction services outside the country, something that Hayes finds unacceptable. “If we want to continue leading the lives we are leading, we have to do our own extraction operations of critical materials ethically.” 

Ethical practices extend as well to current mining employees and can only add to efficiencies that stakeholders demand. Hayes values “helping connect the executive level strategy to the front line, figuring out how to get the front line activated to enact that strategy.” In other words, it's not just about getting employee “buy-in” but demonstrating the “how,” to all of them — operators, maintainers, samplers and surveyors on site — of deploying lofty executive team decisions. “You’re leading people and focused on their safety and well-being and not just managing the tasks at hand,” she says.  

It's all part of Hayes’ “holistic” approach to the issues, of thinking outside the blast hole, as it were, and through the “muck” (a general term in the industry of blasted rock that is ready to be loaded). A thoughtful intervention characterized by the belief that the parts of something are interconnected and can be explained only by reference to the whole is how “defining problems” of our age get solved . . . or at least managed.   

Moving the needle 

In the field.

And clearly for Hayes, it’s not just about operations, safety and profit — or even of financial stakeholders for that matter. It’s about moving the needle in the industry towards not only a greener way of doing things, but a more just and equitable way of doing those things as well.  

 The systemic reimagining of mining is a daunting proposition, and it requires bringing in diverse voices to inform, what Hayes calls, the “broader topics of that broader conversation.” She well remembers being an undergraduate — one of only three or four women in the department. That hasn’t changed much in the last 30 years with most mining organizations reporting only 7-10 percent of a work force made up of women.  

 “The real work needs to be for everyone to understand that a career in mining is a career for the environment, for green energy, and having that will be an attraction for people to come in. [We need to] make it psychologically safe to work in this industry, which it hasn’t always been. It’s work that we all have to do . . . .When you’re trying to tackle these large problems in industry you really need the diversity of thought that comes out of these different mining programs.”  

 The U’s program is no different. As with other institutions of higher education, its metrics of success are research, funding, student enrollment, and student success. “Industry needs to do its part to help create a pipeline of students to the U as well as look to the university to do some of their important research.” “The same holds true in reverse, universities need to be asking industry what will be most impactful for mining of the future.” If things don’t change, mining engineering departments across the country like the U’s will dwindle and die. “We’ve seen that in West Virginia,” she says, referencing beleaguered West Virginia University. In August the flagship Morgantown campus proposed eliminating nine percent of the majors and seven percent of its full-time faculty members.  

Critical materials, critical thought 

Fewer and fewer programs in all academic fields means less and less diversity of thought, which is critically needed. Hayes intends to advocate for better associations between industry and the university for this very reason. It’s a personally held mission that might have not only a macro difference but a micro one as well in these challenging times. She and her husband are the proud parents of another proverbial “miner’s daughter,” and her daughter is likely to be better positioned to consider a degree and a career in mining engineering because of her mother’s continuing hard work in the sector.  

When Denee Hayes recently won an honorary alumna award at the department’s most recent awards ceremony, the coal miner’s daughter had her dad in the room. “He was ecstatic to come and see me.” she says with a smile.  

by David Pace

Cosmic Ray Learning in Public Schools

Cosmic Ray Learning in Public Schools

A cohort of teens at the Salt Lake Center for Science Education (SLCSE) is learning the principles of physics and computer programming by building detectors for cosmic rays.

January 29, 2024

 

^ Professor of physics, Tino Nyawelo coaches a student. ^^ Banner photo above: Ricardo Gonzalez, REFUGES Afterschool Program Coordinator staging an orientation for the cosmic ray program at SLCSE. Credit: Todd Anderson

The pilot program is led by U faculty member Tino Nyawelo, one of three recipients of the 2023 Spirit of Salam Award given annually on the birthday of the famed theoretical physicist from Punjab, Pakistan, Abdus Salam.

The program is an extension of the larger successful REFUGES initiative, designed to support refugee students entering Utah’s public school system, a transition that can often be difficult due to the age-based placement of schools. “[The students] couldn't succeed in this [Utah public] school system because they spent years in refugee camps without any education,” says Nyawelo. “Since we can't change the school system, we have to fill-in by providing additional support.” In addition to hands-on experience with science, the students are also provided with resources for personal health and wellness, college and career readiness and assistance applying for scholarships. Several students from the last cohort have received full-ride scholarships.

Nyawelo emphasizes the importance of this component: “For [students] to succeed, you need to address the costs of education. That's why we have college and career readiness, and we have provided scholarships. They can be smart and all those kinds of things, but if you don't support them and don't provide all those resources, they may not be able to afford to come [to the U], for example.”

Beyond the unique opportunity to engage with real physics, ensuring a viable future path for its participants is one of the program’s vital elements. 

Detectors for Cosmic Ray Science

SLCSE student doing calculations related to the cosmic ray outreach project.

The detector technology is adapted from HiSPARC (High School Project on Astrophysics Research with Cosmics), a program co-founded by physicists Bob van Eijk and Nyawelo’s former advisor Jan-Willem van Holten, a theoretical physicist at Nikhef (the Dutch National Institute for Subatomic Physics) with whom Nyawelo continues to collaborate to this day. Van Holten and a number of researchers who worked on the HiSPARC project have flown to Utah several times to help Nyawelo adapt the program in its new digs in the Mountain West. “I still have a big connection with the Netherlands,” says Nyawelo. “Van Holten, van Eijk, and their colleagues at Nikhef have donated a lot of the equipment to work and build cosmic ray detectors with high school students here in Utah, and they handed me the project that they started more than 20 years ago.”

After the detectors are installed at SLCSE and begin collecting data, there is a continual opportunity for the students to learn coding skills and data analysis as part of their physics and astronomy curriculum. The database is an international one, with data dumps coming in from all over the world, in real-time. The program is designed to scale up to other high schools throughout the state so that students can have hands-on experience collecting and analyzing data about cosmic rays globally. “It’s been an exciting project that can serve as a model for other places that want to support students from these backgrounds to succeed in STEM in higher education, just like I did while attending the ICTP [Abdus Salam International Centre for Theoretical Physics in Italy] and in the Netherlands.” 

Generous support for the pilot program at SLCSE was provided by Jeff and Pauline Unruh through the Unruh Family Foundation. "Our foundation focuses on STEM disciplines and inspiring young minds. [This] is a perfect example. We're proud to support the next generation of scientists," says Jeff. "With his commendable dedication to this program, Nyawelo has ensured that these students will walk away not just with extensive hands-on experience in STEM, but also with the tools to succeed in their lives beyond the classroom, fostering a brighter and more accessible future for science." 

By Julia St. Andre

How long can menopause be delayed?

How long can menopause be delayed?

At birth, ovaries in girls can contain about a million tiny structures called primordial follicles, each of which contains an egg cell. As girls grow and experience adulthood, most of these follicles will die while only one follicle will survive each month to ovulate a mature egg.

^Sean Lawley. ^^Banner photo above: “The 28 Day Cycle," a temporary art installation of a three-dimensional bar graph of the ebb and flow of menstruation by biology/art/pre-med student Danielle Okelberry, debuted at the U's Aline Skaggs Biology building in 2022.

When the loss of primordial follicles is nearly complete, and only hundreds remain, women experience menopause, a time when menstrual cycles have ceased for 12 months.New research, which relies on a mathematical model developed by a University of Utah mathematician, indicates that it is possible to delay the onset of menopause, perhaps indefinitely, by implanting a woman’s own previously harvested ovarian tissue back into her body. This technique has been successfully used to restore fertility in cancer patients, according to Sean Lawley, associate professor of mathematics and co-author of a study published Friday in the American Journal of Obstetrics and Gynecology, or AJOG.

This interdisciplinary work is a collaboration between Lawley, Joshua Johnson, an ovarian biologist at the University of Colorado School of Medicine; Jay Emerson, professor of statistics and data science at Yale University; and Kutluk Oktay, a prominent physician, professor of obstetrics, gynecology, and reproductive sciences and ovarian biologist at Yale School of Medicine. In the late 1990s, Oktay developed ways to harvest ovarian tissue from young cancer patients, freeze it (“cryopreserve” it), and then transplant it after she has undergone cancer treatments that would have left her menopausal and infertile. This the technique is referred to as “ovarian tissue cryopreservation and transplantation.”

The technique has enabled hundreds of cancer survivors to conceive and have children. It is substantially different from the common procedure of freezing eggs, which is effective in helping older women conceive through in vitro fertilization, but has no impact on menopause.

 

Read the entire article by Brian Maffly in @TheU.


Read more about the art installation featured above here.

Preeminent geneticists recognized with revamped GSA Awards

OFer Rog, GSA AWARD

In 2022, Genetics Society of America’s Board of Directors launched an audit to review the five major awards conferred by the Society. On January 11th, the organization announced the recipients of the reimagined GSA Awards, including Ofer Rog who won the new Early Career Medal, recognizing "outstanding contributions to the field of genetics."

Rog is recognized for work visualizing meiotic exchange between sisters, exploring synaptonemal complex proteins, and tracking single molecules. Additionally, Rog’s efforts to recruit and maintain a diverse student body at the University of Utah and support LGBTQ+ students are commendable and an inspiration to many in the field.

The scientists honored this year are recognized by their peers for their outstanding contributions to research and education and their distinguished service in the field of genetics. They will be presented with their awards at The Allied Genetics Conference 2024 taking place March 6-10, 2024, in Metro Washington, DC. Throughout the rest of the year, a series of profiles published in Genes to Genomes and virtual awards seminars will provide more insight into their inspiring careers.

Read about all of the awardees here.

 

 

Measuring Co2 levels

Measuring CO2 levels over the past 66 million years

Although 800,000 years may seem like a long time, when it comes to measuring important data, like CO2 levels, 800,000 years is just a blink of an eye.

 In order to gain a better understanding of the changes in CO2 levels and their fluctuations over geologic time, geoscientists have now been able to go back 66 million years.

But why is it important to measure CO2 levels over such a long span of time? And how does the current CO2 levels of 419 parts per million fit in earth’s history?

To answer this, and many more questions, Gabe Bowen, a geology professor at the University of Utah and a corresponding author of the recent study mapping changes in atmospheric CO2 over the past 66 million years, joins Cool Science Radio.

 

Listen to the podcast with Gabe Bowen on KPCW's Cool Science Radio.

Ken Golden, Op-ed

Space Race? we can win the ‘Earth Race’ too

Alta Ski Resort, just outside of Salt Lake City, received a whopping 903 inches of snow last winter, delighting skiers with continuous fresh powder. But Utah’s snowpack and precipitation patterns are of interest not just to ski resorts; they are of critical importance to the state’s drinking water, agriculture, industry and the health of the Great Salt Lake.

Was this the start of a period of abundant precipitation for the state or an aberration — a last gasp before the climate here settles into a drier equilibrium?

There is a propensity on both sides of the political aisle to become entrenched in partisan policy approaches, making it difficult to navigate our way through an uncertain and rapidly changing environment. However, I see these challenges as an opportunity to spearhead new technologies, innovations and policies that balance current economics and investments with our shifting circumstances. What might seem to be a setback must instead be viewed as a launching pad for our next giant leap forward.

The last time the U.S. was presented with an opportunity on this scale, which also arose from a threat to our way of life and to national security, was the Space Race of the 1960s. Scientific and technological advances were ignited by the challenges that humans faced when we first set our sights on landing on the moon. Our government, partnering with federal agencies and academia, demonstrated its resolve to defeat the Soviet Union in a race to the lunar surface. This initiative triggered investment across our economy, in universities and in technological infrastructure, spawning new markets and industries, creating jobs and sparking revolutionary advances in STEM fields and beyond. American science was viewed with pride at home and abroad.

In this new “Earth Race,” we have an opportunity for incredible innovation and progress. We can work collaboratively to promote science-based approaches while ensuring that current economic engines have the resources to adapt to new realities. However, if we fail to act, we will be left behind as other countries take the lead in creating a sustainable and economically vibrant future.

We cannot afford not to use the full power of American ingenuity, entrepreneurship and the world’s best university system if we are to seize the historic moment that we are in to fuel potent change. By many metrics we are already losing this race, as well as the spoils that will go to the leader of the global-scale technological transition that is just getting started.

China, for example, has doubled funding for higher education and, by 2025, will be producing around 80,000 STEM Ph.D.s per year — twice as many as the U.S.

China’s spending on research and development has jumped to 2.56 percent of GDP, though some of that funding is coming from businesses; still, that is more than triple the U.S. federal investment of 0.7 percent, which has been in decline for over a decade. Furthermore, China recently overtook the U.S. in science and engineering publications, and in 2022 ranked No. 1 in contributions to the prestigious Nature group of science journals, surpassing us for the first time.

We can’t risk lagging behind for much longer. Let’s set the not-so-lofty goal of catching up over the next eight years to our principal global rival by tripling federal R&D investment in math, science and engineering, and doubling our STEM Ph.D.s.

Significantly increased funding and attention to STEM research and education can be the catalyst for the U.S. to win the Earth Race, as well as spawn breakthroughs on other critical fronts. It will accelerate advances important not only for climate solutions but to the future of our national economy and defense posture, in fields such as quantum computing, AI, data science, medicine, optimization, advanced materials, photonics and energy storage.

We’re all in the same boat: planet Earth! The sheer complexity, scope and highly interdisciplinary nature of climate issues necessitate that we work together, across ideological, academic, intellectual and political lines, to achieve big goals that will benefit all of us. These problems are solvable. We have the talent, the ingenuity and the motivation to succeed. Increased investment in STEM, with our sights set on winning the Earth Race, will jumpstart our economy through the development of new solutions and will pay substantial dividends as we sail forward.

Let us set the compass toward our highest aspirations: “through adversity to the stars.”

By Kenneth M. Golden

 

 

 

Kenneth M. Golden is a distinguished professor of mathematics and adjunct professor of biomedical engineering at the University of Utah.  This opinion piece originally appeared January 12, 2024 in The Hill, Washington D.C.